Protein-S-isoprenylcysteine O-methyltransferase

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In enzymology, a protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine $\rightleftharpoons$ S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester

Thus, the two substrates of this enzyme are S-adenosyl methionine and protein C-terminal S-farnesyl-L-cysteine, whereas its two products are S-adenosylhomocysteine and protein C-terminal S-farnesyl-L-cysteine methyl ester.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase. Other names in common use include farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, protein C-terminal farnesylcysteine O-methyltransferase, farnesylated protein C-terminal O-methyltransferase, isoprenylated protein methyltransferase, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, prenylcysteine carboxylmethyltransferase [misleading], prenylcysteine carboxymethyltransferase [misleading], and prenylcysteine methyltransferase.

[edit] References

IUBMB entry for 2.1.1.100
BRENDA references for 2.1.1.100 (Recommended.)
PubMed references for 2.1.1.100
PubMed Central references for 2.1.1.100
Google Scholar references for 2.1.1.100
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Ota IM, Clarke S (1989). "Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for methyl ester formation at carboxyl-terminal cysteinyl residues". J. Biol. Chem. 264: 12879–84. PMID 2753892.
Stephenson RC, Clarke S (1990). "Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate". J. Biol. Chem. 265: 16248–54. PMID 2398053.