Propionyl-CoA C2-trimethyltridecanoyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a propionyl-CoA C2-trimethyltridecanoyltransferase (EC 2.3.1.154) is an enzyme that catalyzes the chemical reaction

4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA $\rightleftharpoons$ 3-oxopristanoyl-CoA + CoA

Thus, the two substrates of this enzyme are 4,8,12-trimethyltridecanoyl-CoA and propanoyl-CoA, whereas its two products are 3-oxopristanoyl-CoA and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase. Other names in common use include 3-oxopristanoyl-CoA hydrolase, 3-oxopristanoyl-CoA thiolase, peroxisome sterol carrier protein thiolase, sterol carrier protein, oxopristanoyl-CoA thiolase, peroxisomal 3-oxoacyl coenzyme A thiolase, SCPx, 4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA, and 2-C-4,8,12-trimethyltridecanoyltransferase.

[edit] References

IUBMB entry for 2.3.1.154
BRENDA references for 2.3.1.154 (Recommended.)
PubMed references for 2.3.1.154
PubMed Central references for 2.3.1.154
Google Scholar references for 2.3.1.154
Seedorf U, Brysch P, Engel T, Schrage K, Assmann G (1994). "Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity". J. Biol. Chem. 269: 21277–83. PMID 8063752.
Wanders RJ, Denis S, Wouters F, Wirtz KW, Seedorf U (1997). "Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes". Biochem. Biophys. Res. Commun. 236: 565–9. doi:10.1006/bbrc.1997.7007. PMID 9245689.