PRKRA

From Wikipedia, the free encyclopedia

Protein kinase, interferon-inducible double stranded RNA dependent activator

PDB rendering based on 2dix.

Available structures: 2dix

Identifiers

Symbol(s)

PRKRA; HSD14; PACT; RAX

External IDs

OMIM: 603424 MGI: 1344375 HomoloGene: 2738

Gene ontology
Molecular Function:	• double-stranded RNA binding • signal transducer activity • protein binding • enzyme activator activity
Cellular Component:	• intracellular • cytoplasm
Biological Process:	• protein amino acid phosphorylation • induction of apoptosis • response to stress • immune response • signal transduction • negative regulation of cell proliferation • response to virus • outer ear morphogenesis • middle ear morphogenesis • skeletal morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003690 (mRNA)
NP_003681 (protein)

NM_011871 (mRNA)
NP_036001 (protein)

Location

Chr 2: 179 - 179.02 Mb

Chr 2: 76.43 - 76.45 Mb

Pubmed search

[1]

[2]

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as PRKRA, is a human gene.^[1]

[edit] References

^ Entrez Gene: PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Simons A, Melamed-Bessudo C, Wolkowicz R, et al. (1997). "PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb.". Oncogene 14 (2): 145-55. doi:10.1038/sj.onc.1200825. PMID 9010216.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Patel RC, Sen GC (1998). "PACT, a protein activator of the interferon-induced protein kinase, PKR.". EMBO J. 17 (15): 4379-90. doi:10.1093/emboj/17.15.4379. PMID 9687506.
Ito T, Yang M, May WS (1999). "RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling.". J. Biol. Chem. 274 (22): 15427-32. PMID 10336432.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Horng T, Barton GM, Medzhitov R (2001). "TIRAP: an adapter molecule in the Toll signaling pathway.". Nat. Immunol. 2 (9): 835-41. doi:10.1038/ni0901-835. PMID 11526399.
Huang X, Hutchins B, Patel RC (2002). "The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).". Biochem. J. 366 (Pt 1): 175-86. doi:10.1042/BJ20020204. PMID 11985496.
Peters GA, Khoo D, Mohr I, Sen GC (2002). "Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein.". J. Virol. 76 (21): 11054-64. PMID 12368348.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yang M, Ito T, May WS (2003). "A novel role for RAX, the cellular activator of PKR, in synergistically stimulating SV40 large T antigen-dependent gene expression.". J. Biol. Chem. 278 (40): 38325-32. doi:10.1074/jbc.M303420200. PMID 12874289.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Bennett RL, Blalock WL, May WS (2004). "Serine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibition.". J. Biol. Chem. 279 (41): 42687-93. doi:10.1074/jbc.M403321200. PMID 15299031.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Lee Y, Hur I, Park SY, et al. (2006). "The role of PACT in the RNA silencing pathway.". EMBO J. 25 (3): 522-32. doi:10.1038/sj.emboj.7600942. PMID 16424907.
Bennett RL, Blalock WL, Abtahi DM, et al. (2006). "RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection.". Blood 108 (3): 821-9. doi:10.1182/blood-2005-11-006817. PMID 16861340.