PRKDC

From Wikipedia, the free encyclopedia

Protein kinase, DNA-activated, catalytic polypeptide

Identifiers

PRKDC; DNAPK; DNPK1; HYRC; HYRC1; XRCC7; p350

External IDs

OMIM: 600899 MGI: 104779 HomoloGene: 5037

Gene ontology
Molecular Function:	• DNA binding • DNA-dependent protein kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• telomere maintenance • somitogenesis • double-strand break repair via nonhomologous end joining • DNA recombination • protein modification process • apoptosis • brain development • heart development

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001081640 (mRNA)
NP_001075109 (protein)

NM_011159 (mRNA)
NP_035289 (protein)

Location

n/a

Chr 16: 15.55 - 15.76 Mb

Pubmed search

[1]

[2]

Protein kinase, DNA-activated, catalytic polypeptide, also known as PRKDC, is a human gene.

The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.[supplied by OMIM]^[1]

[edit] See also

Protein kinase

[edit] References

^ Entrez Gene: PRKDC protein kinase, DNA-activated, catalytic polypeptide.

[edit] Further reading

Giaccia AJ, Kastan MB (1998). "The complexity of p53 modulation: emerging patterns from divergent signals.". Genes Dev. 12 (19): 2973-83. PMID 9765199.
Collis SJ, DeWeese TL, Jeggo PA, Parker AR (2005). "The life and death of DNA-PK.". Oncogene 24 (6): 949-61. doi:10.1038/sj.onc.1208332. PMID 15592499.
Van Maele B, Debyser Z (2005). "HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins.". AIDS reviews 7 (1): 26-43. PMID 15875659.