PRKACG

From Wikipedia, the free encyclopedia

Protein kinase, cAMP-dependent, catalytic, gamma

Identifiers

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • cAMP-dependent protein kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• cytoplasm • mitochondrion • neuromuscular junction
Biological Process:	• mesoderm formation • protein amino acid phosphorylation • spermatogenesis • male gonad development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_002732 (mRNA)
NP_002723 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 9: 70.82 - 70.82 Mb

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Pubmed search

[1]

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Protein kinase, cAMP-dependent, catalytic, gamma, also known as PRKACG, is a human gene.^[1]

Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.^[1]

[edit] References

^ ^a ^b Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma.

[edit] Further reading

Foss KB, Simard J, Bérubé D, et al. (1992). "Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13.". Cytogenet. Cell Genet. 60 (1): 22–5. PMID 1339328.
Hofmann B, Nishanian P, Baldwin RL, et al. (1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism.". J. Immunol. 145 (11): 3699–705. PMID 1978848.
Beebe SJ, Oyen O, Sandberg M, et al. (1990). "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.". Mol. Endocrinol. 4 (3): 465–75. PMID 2342480.
Hofmann B, Nishanian P, Nguyen T, et al. (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. PMID 7688126.
Hofmann B, Nishanian P, Fan J, et al. (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro.". AIDS 8 (7): 1016–7. PMID 7946090.
Swingler S, Gallay P, Camaur D, et al. (1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.". J. Virol. 71 (6): 4372–7. PMID 9151826.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. PMID 9278385.
Liapi C, Takahashi N, Raynaud F, et al. (1998). "Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts.". J. Invest. Dermatol. 110 (4): 332–7. doi:10.1046/j.1523-1747.1998.00149.x. PMID 9540970.
Reinton N, Haugen TB, Orstavik S, et al. (1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon.". Genomics 49 (2): 290–7. doi:10.1006/geno.1998.5240. PMID 9598317.
Zidovetzki R, Wang JL, Chen P, et al. (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.". AIDS Res. Hum. Retroviruses 14 (10): 825–33. PMID 9671211.
Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3-4): 184–92. PMID 9730685.
Bodnar RJ, Xi X, Li Z, et al. (2003). "Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta).". J. Biol. Chem. 277 (49): 47080–7. doi:10.1074/jbc.M208329200. PMID 12361948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cartier C, Hemonnot B, Gay B, et al. (2003). "Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein.". J. Biol. Chem. 278 (37): 35211–9. doi:10.1074/jbc.M301257200. PMID 12842892.
Masci AM, Galgani M, Cassano S, et al. (2004). "HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling.". J. Leukoc. Biol. 74 (6): 1117–24. doi:10.1189/jlb.0503239. PMID 12972513.
Zhang W, Morris GZ, Beebe SJ (2004). "Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells.". Protein Expr. Purif. 35 (1): 156–69. doi:10.1016/j.pep.2004.01.006. PMID 15039079.
Stevanin G, Hahn V, Lohmann E, et al. (2004). "Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14.". Arch. Neurol. 61 (8): 1242–8. doi:10.1001/archneur.61.8.1242. PMID 15313841.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.