PRKAB2

From Wikipedia, the free encyclopedia


Protein kinase, AMP-activated, beta 2 non-catalytic subunit
PDB rendering based on 2f15.
Available structures: 2f15
Identifiers
Symbol(s) PRKAB2; MGC61468
External IDs OMIM: 602741 MGI: 1336185 HomoloGene: 38046
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5565 108097
Ensembl ENSG00000131791 ENSMUSG00000038205
Uniprot O43741 Q7TQI6
Refseq NM_005399 (mRNA)
NP_005390 (protein)		 NM_182997 (mRNA)
NP_892042 (protein)
Location Chr 1: 145.09 - 145.11 Mb Chr 3: 97.74 - 97.76 Mb
Pubmed search [1] [2]

Protein kinase, AMP-activated, beta 2 non-catalytic subunit, also known as PRKAB2, is a human gene.[1]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.[1]

[edit] References

  1. ^ a b Entrez Gene: PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit.

[edit] Further reading

  • Stapleton D, Mitchelhill KI, Gao G, et al. (1996). "Mammalian AMP-activated protein kinase subfamily.". J. Biol. Chem. 271 (2): 611–4. PMID 8557660. 
  • Gao G, Fernandez CS, Stapleton D, et al. (1996). "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase.". J. Biol. Chem. 271 (15): 8675–81. PMID 8621499. 
  • Woods A, Cheung PC, Smith FC, et al. (1996). "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro.". J. Biol. Chem. 271 (17): 10282–90. PMID 8626596. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Stapleton D, Woollatt E, Mitchelhill KI, et al. (1997). "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.". FEBS Lett. 409 (3): 452–6. PMID 9224708. 
  • Thornton C, Snowden MA, Carling D (1998). "Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle.". J. Biol. Chem. 273 (20): 12443–50. PMID 9575201. 
  • Cheung PC, Salt IP, Davies SP, et al. (2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.". Biochem. J. 346 Pt 3: 659–69. PMID 10698692. 
  • Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456. 
  • Park SH, Paulsen SR, Gammon SR, et al. (2003). "Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle.". J. Appl. Physiol. 93 (6): 2081–8. doi:10.1152/japplphysiol.00504.2002. PMID 12433937. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Prochazka M, Farook VS, Ossowski V, et al. (2003). "Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians.". Mol. Cell. Probes 16 (6): 421–7. PMID 12490143. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Minokoshi Y, Alquier T, Furukawa N, et al. (2004). "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.". Nature 428 (6982): 569–74. doi:10.1038/nature02440. PMID 15058305. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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