Prephenate dehydrogenase (NADP+)

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In enzymology, a prephenate dehydrogenase (NADP+) (EC 1.3.1.13) is an enzyme that catalyzes the chemical reaction

prephenate + NADP⁺ 4-hydroxyphenylpyruvate + CO₂ + NADPH

Thus, the two substrates of this enzyme are prephenate and NADP⁺, whereas its 3 products are 4-hydroxyphenylpyruvate, CO₂, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is prephenate:NADP+ oxidoreductase (decarboxylating). Other names in common use include prephenate dehydrogenase, prephenate (nicotinamide adenine dinucleotide phosphate), dehydrogenase, and prephenate dehydrogenase (NADP). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

[edit] References

• IUBMB entry for 1.3.1.13
• BRENDA references for 1.3.1.13 (Recommended.)
• PubMed references for 1.3.1.13
• PubMed Central references for 1.3.1.13
• Google Scholar references for 1.3.1.13
• Gamborg OL, Keeley FW (1966). "Aromatic metabolism in plants. I. A study of the prephenate dehydrogenase from bean plants". Biochim. Biophys. Acta. 115: 65–72. PMID 4379953. 

[edit] External links

The CAS registry number for this enzyme class is 37251-11-9.

• IUBMB entry for 1.3.1.13

• KEGG entry for 1.3.1.13

• BRENDA entry for 1.3.1.13

• NiceZyme view of 1.3.1.13

• EC2PDB: PDB structures for 1.3.1.13

• PRIAM entry for 1.3.1.13

• PUMA2 entry for 1.3.1.13

• IntEnz: Integrated Enzyme entry for 1.3.1.13

• MetaCyc entry for 1.3.1.13

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004665: prephenate dehydrogenase (NADP+)

• AMIGO entry for GO code 0004665: prephenate dehydrogenase (NADP+)