Prephenate dehydrogenase
From Wikipedia, the free encyclopedia
In enzymology, a prephenate dehydrogenase (EC 1.3.1.12) is an enzyme that catalyzes the chemical reaction
- prephenate + NAD+
4-hydroxyphenylpyruvate + CO2 + NADH
Thus, the two substrates of this enzyme are prephenate and NAD+, whereas its 3 products are 4-hydroxyphenylpyruvate, CO2, and NADH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is prephenate:NAD+ oxidoreductase (decarboxylating). Other names in common use include hydroxyphenylpyruvate synthase, and chorismate mutase---prephenate dehydrogenase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and novobiocin biosynthesis.
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[edit] Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2G5C and 2PV7.
[edit] References
- IUBMB entry for 1.3.1.12
- BRENDA references for 1.3.1.12 (Recommended.)
- PubMed references for 1.3.1.12
- PubMed Central references for 1.3.1.12
- Google Scholar references for 1.3.1.12
- Koch GL, Shaw DC, Gibson F (1970). "Tyrosine biosynthesis in Aerobacter aerogenes. Purification and properties of chorismate mutase-prephenate dehydrogenase". Biochim. Biophys. Acta. 212: 375–86. PMID 5456988.
[edit] External links
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- The CAS registry number for this enzyme class is 9044-92-2.
[edit] Gene Ontology (GO) codes
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