Precorrin-6Y C5,15-methyltransferase (decarboxylating)

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In enzymology, a precorrin-6Y C5,15-methyltransferase (decarboxylating) (EC 2.1.1.132) is an enzyme that catalyzes the chemical reaction

2 S-adenosyl-L-methionine + precorrin-6Y $\rightleftharpoons$ 2 S-adenosyl-L-homocysteine + precorrin-8X + CO₂

Thus, the two substrates of this enzyme are S-adenosyl methionine and precorrin 6Y, whereas its 3 products are S-adenosylhomocysteine, precorrin 8X, and CO₂.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating). Other names in common use include precorrin-6 methyltransferase, and precorrin-6Y methylase. This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

IUBMB entry for 2.1.1.132
BRENDA references for 2.1.1.132 (Recommended.)
PubMed references for 2.1.1.132
PubMed Central references for 2.1.1.132
Google Scholar references for 2.1.1.132
Blanche F, Famechon A, Thibaut D, Debussche L, Cameron B, Crouzet J (1992). "Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6y to precorrin-8x is catalyzed by the cobL gene product". J. Bacteriol. 174: 1050–2. PMID 1732195.