Precorrin-6A synthase (deacetylating)

From Wikipedia, the free encyclopedia

In enzymology, a precorrin-6A synthase (deacetylating) (EC 2.1.1.152) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + precorrin-5 + H₂O S-adenosyl-L-homocysteine + precorrin-6A + acetate

The 3 substrates of this enzyme are S-adenosyl methionine, precorrin 5, and H₂O, whereas its 3 products are S-adenosylhomocysteine, precorrin 6A, and acetate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating). Other names in common use include precorrin-6X synthase (deacetylating), and CobF. This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

• IUBMB entry for 2.1.1.152
• BRENDA references for 2.1.1.152 (Recommended.)
• PubMed references for 2.1.1.152
• PubMed Central references for 2.1.1.152
• Google Scholar references for 2.1.1.152
• Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F (1993). "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". J. Bacteriol. 175: 7430–40. PMID 8226690. 
• Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19: 390–412. doi:10.1039/b108967f. PMID 12195810. 

[edit] External links

• IUBMB entry for 2.1.1.152

• KEGG entry for 2.1.1.152

• BRENDA entry for 2.1.1.152

• NiceZyme view of 2.1.1.152

• EC2PDB: PDB structures for 2.1.1.152

• PRIAM entry for 2.1.1.152

• PUMA2 entry for 2.1.1.152

• IntEnz: Integrated Enzyme entry for 2.1.1.152

• MetaCyc entry for 2.1.1.152

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043819: precorrin-6A synthase (deacetylating)

• AMIGO entry for GO code 0043819: precorrin-6A synthase (deacetylating)