PRB3

From Wikipedia, the free encyclopedia

Proline-rich protein BstNI subfamily 3

Identifiers

PRB3; G1; MGC116862; MGC116863; MGC116864; PRG

External IDs

OMIM: 168840 MGI: 3644500 HomoloGene: 79501

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • molecular_function • Gram-negative bacterial binding
Cellular Component:	• cellular_component • extracellular region • integral to membrane
Biological Process:	• G-protein coupled receptor protein signaling pathway • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

XM_001128803 (mRNA)
XP_001128803 (protein)

XM_899032 (mRNA)
XP_904125 (protein)

Location

Chr 12: 11.31 - 11.31 Mb

n/a

Pubmed search

[1]

[2]

Proline-rich protein BstNI subfamily 3, also known as PRB3, is a human gene.^[1]

The protein encoded by this gene is a proline-rich salivary protein. It is a major constituent of parotid saliva. This protein is proposed to act as a bacterial receptor. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.^[1]

[edit] References

^ ^a ^b Entrez Gene: PRB3 proline-rich protein BstNI subfamily 3.

[edit] Further reading

Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their polymorphisms.". Adv. Hum. Genet. 17: 141–99. PMID 3055850.
Gillece-Castro BL, Prakobphol A, Burlingame AL, et al. (1991). "Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein.". J. Biol. Chem. 266 (26): 17358–68. PMID 1894623.
Azen EA, Minaguchi K, Latreille P, Kim HS (1990). "Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew.". Am. J. Hum. Genet. 47 (4): 686–97. PMID 2171329.
Lyons KM, Stein JH, Smithies O (1989). "Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over.". Genetics 120 (1): 267–78. PMID 2851479.
Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system.". J. Biol. Chem. 260 (20): 11123–30. PMID 2993301.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Azen E, Prakobphol A, Fisher SJ (1993). "PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro.". Infect. Immun. 61 (10): 4434–9. PMID 8406834.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.