PPIF

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Peptidylprolyl isomerase F (cyclophilin F)

PDB rendering based on 2bit.

Available structures: 2bit, 2biu

Identifiers

Symbol(s)

PPIF; CYP3; Cyp-D; FLJ90798; MGC117207

External IDs

OMIM: 604486 MGI: 2145814 HomoloGene: 38696

Gene ontology
Molecular Function:	• peptidyl-prolyl cis-trans isomerase activity • isomerase activity • peptide binding
Cellular Component:	• membrane fraction • mitochondrion
Biological Process:	• protein folding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005729 (mRNA)
NP_005720 (protein)

NM_134084 (mRNA)
NP_598845 (protein)

Location

Chr 10: 80.78 - 80.79 Mb

Chr 14: 24.53 - 24.53 Mb

Pubmed search

[1]

[2]

Peptidylprolyl isomerase F (cyclophilin F), also known as PPIF, is a human gene.^[1]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.^[1]

[edit] References

^ ^a ^b Entrez Gene: PPIF peptidylprolyl isomerase F (cyclophilin F).

[edit] Further reading

Bergsma DJ, Eder C, Gross M, et al. (1992). "The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.". J. Biol. Chem. 266 (34): 23204-14. PMID 1744118.
Crompton M, Virji S, Ward JM (1999). "Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore.". Eur. J. Biochem. 258 (2): 729-35. PMID 9874241.
Bowles KR, Zintz C, Abraham SE, et al. (2000). "Genomic characterization of the human peptidyl-prolyl-cis-trans-isomerase, mitochondrial precursor gene: assessment of its role in familial dilated cardiomyopathy.". Hum. Genet. 105 (6): 582-6. PMID 10647893.
Bowles KR, Abraham SE, Brugada R, et al. (2000). "Construction of a high-resolution physical map of the chromosome 10q22-q23 dilated cardiomyopathy locus and analysis of candidate genes.". Genomics 67 (2): 109-27. doi:10.1006/geno.2000.6242. PMID 10903836.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298.
Lin DT, Lechleiter JD (2002). "Mitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization.". J. Biol. Chem. 277 (34): 31134-41. doi:10.1074/jbc.M112035200. PMID 12077116.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.