PPEF1

From Wikipedia, the free encyclopedia

Protein phosphatase, EF-hand calcium binding domain 1

Identifiers

PPEF1; PP7; PPEF; PPP7C

External IDs

OMIM: 300109 MGI: 1097157 HomoloGene: 55960

Gene ontology
Molecular Function:	• magnesium ion binding • protein serine/threonine phosphatase activity • iron ion binding • calcium ion binding • hydrolase activity • manganese ion binding
Biological Process:	• protein amino acid dephosphorylation • detection of stimulus during sensory perception

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006240 (mRNA)
NP_006231 (protein)

XM_142281 (mRNA)
XP_142281 (protein)

Location

Chr X: 18.62 - 18.76 Mb

Chr X: 155.99 - 156.08 Mb

Pubmed search

[1]

[2]

Protein phosphatase, EF-hand calcium binding domain 1, also known as PPEF1, is a human gene.^[1]

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: PPEF1 protein phosphatase, EF-hand calcium binding domain 1.

[edit] Further reading

Herzig S, Neumann J (2000). "Effects of serine/threonine protein phosphatases on ion channels in excitable membranes.". Physiol. Rev. 80 (1): 173–210. PMID 10617768.
Montini E, Rugarli EI, Van de Vosse E, et al. (1997). "A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.". Hum. Mol. Genet. 6 (7): 1137–45. PMID 9215685.
Sherman PM, Sun H, Macke JP, et al. (1997). "Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11639–44. PMID 9326663.
Huang X, Honkanen RE (1998). "Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC).". J. Biol. Chem. 273 (3): 1462–8. PMID 9430683.
Ramulu P, Kennedy M, Xiong WH, et al. (2001). "Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2).". Mol. Cell. Biol. 21 (24): 8605–14. doi:10.1128/MCB.21.24.8605-8614.2001. PMID 11713293.
Kutuzov MA, Solov'eva OV, Andreeva AV, Bennett N (2002). "Protein Ser/Thr phosphatases PPEF interact with calmodulin.". Biochem. Biophys. Res. Commun. 293 (3): 1047–52. doi:10.1016/S0006-291X(02)00338-8. PMID 12051765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.