POU2AF1

From Wikipedia, the free encyclopedia

POU domain, class 2, associating factor 1

PDB rendering based on 1cqt.

Available structures: 1cqt

Identifiers

Symbol(s)

POU2AF1; BOB1; OBF-1; OBF1; OCAB

External IDs

OMIM: 601206 MGI: 105086 HomoloGene: 4543

Gene ontology
Molecular Function:	• DNA binding • transcription coactivator activity • protein binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • humoral immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006235 (mRNA)
NP_006226 (protein)

NM_011136 (mRNA)
NP_035266 (protein)

Location

Chr 11: 110.73 - 110.76 Mb

Chr 9: 50.97 - 50.99 Mb

Pubmed search

[1]

[2]

POU domain, class 2, associating factor 1, also known as POU2AF1, is a human gene.^[1]

[edit] References

^ Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1.

[edit] Further reading

Teitell MA (2004). "OCA-B regulation of B-cell development and function.". Trends Immunol. 24 (10): 546–53. PMID 14552839.
Luo Y, Roeder RG (1995). "Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B.". Mol. Cell. Biol. 15 (8): 4115–24. PMID 7623806.
Gstaiger M, Knoepfel L, Georgiev O, et al. (1995). "A B-cell coactivator of octamer-binding transcription factors.". Nature 373 (6512): 360–2. doi:10.1038/373360a0. PMID 7779176.
Strubin M, Newell JW, Matthias P (1995). "OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins.". Cell 80 (3): 497–506. PMID 7859290.
Galiègue-Zouitina S, Quief S, Hildebrand MP, et al. (1996). "Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation.". C. R. Acad. Sci. III, Sci. Vie 318 (11): 1125–31. PMID 8574789.
Junker S, Brøndum-Nielsen K, Newell JW, et al. (1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization.". Genomics 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501.
Zwilling S, Dieckmann A, Pfisterer P, et al. (1997). "Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells.". Science 277 (5323): 221–5. PMID 9211847.
Sauter P, Matthias P (1998). "The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction.". Immunobiology 198 (1-3): 207–16. PMID 9442392.
Luo Y, Ge H, Stevens S, et al. (1998). "Coactivation by OCA-B: definition of critical regions and synergism with general cofactors.". Mol. Cell. Biol. 18 (7): 3803–10. PMID 9632764.
Sauter P, Matthias P (1998). "Coactivator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA.". Mol. Cell. Biol. 18 (12): 7397–409. PMID 9819426.
Chasman D, Cepek K, Sharp PA, Pabo CO (1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface.". Genes Dev. 13 (20): 2650–7. PMID 10541551.
Tomilin A, Reményi A, Lins K, et al. (2001). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration.". Cell 103 (6): 853–64. PMID 11136971.
Lee L, Stollar E, Chang J, et al. (2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator.". Biochemistry 40 (22): 6580–8. PMID 11380252.
Tiedt R, Bartholdy BA, Matthias G, et al. (2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1.". EMBO J. 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. PMID 11483517.
Boehm J, He Y, Greiner A, et al. (2001). "Regulation of BOB.1/OBF.1 stability by SIAH.". EMBO J. 20 (15): 4153–62. doi:10.1093/emboj/20.15.4153. PMID 11483518.
Malone CS, Wall R (2002). "Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific B29 (Ig beta) and mb-1 (Ig alpha) promoters.". J. Immunol. 168 (7): 3369–75. PMID 11907094.
Casellas R, Jankovic M, Meyer G, et al. (2003). "OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes.". Cell 110 (5): 575–85. PMID 12230975.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Schaffer A, Kim EC, Wu X, et al. (2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements.". J. Biol. Chem. 278 (25): 23141–50. doi:10.1074/jbc.M212952200. PMID 12672812.
Lins K, Reményi A, Tomilin A, et al. (2003). "OBF1 enhances transcriptional potential of Oct1.". EMBO J. 22 (9): 2188–98. doi:10.1093/emboj/cdg199. PMID 12727885.