POM121

From Wikipedia, the free encyclopedia

POM121 membrane glycoprotein (rat)

Identifiers

POM121; DKFZP586G1822; DKFZP586P2220; KIAA0618; MGC3792

External IDs

Gene ontology
Cellular Component:	• nucleus • nuclear pore • endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• protein targeting • protein transport • mRNA transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

XM_001130619 (mRNA)
XP_001130619 (protein)

NM_148932 (mRNA)
NP_683734 (protein)

Location

Chr 7: 71.99 - 72.06 Mb

Chr 5: 135.66 - 135.68 Mb

Pubmed search

[1]

[2]

POM121 membrane glycoprotein (rat), also known as POM121, is a human gene.^[1]

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: POM121 POM121 membrane glycoprotein (rat).

[edit] Further reading

Bodoor K, Shaikh S, Enarson P, et al. (1999). "Function and assembly of nuclear pore complex proteins.". Biochem. Cell Biol. 77 (4): 321–9. PMID 10546895.
Kipersztok S, Osawa GA, Liang LF, et al. (1995). "POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue.". Genomics 25 (2): 354–9. PMID 7789967.
Hallberg E, Wozniak RW, Blobel G (1993). "An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region.". J. Cell Biol. 122 (3): 513–21. PMID 8335683.
Fouchier RA, Meyer BE, Simon JH, et al. (1998). "Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex.". J. Virol. 72 (7): 6004–13. PMID 9621063.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811.
Daigle N, Beaudouin J, Hartnell L, et al. (2001). "Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells.". J. Cell Biol. 154 (1): 71–84. PMID 11448991.
Kihlmark M, Imreh G, Hallberg E (2002). "Sequential degradation of proteins from the nuclear envelope during apoptosis.". J. Cell. Sci. 114 (Pt 20): 3643–53. PMID 11707516.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Eriksson C, Rustum C, Hallberg E (2004). "Dynamic properties of nuclear pore complex proteins in gp210 deficient cells.". FEBS Lett. 572 (1-3): 261–5. doi:10.1016/j.febslet.2004.07.044. PMID 15304359.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.