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Pathogen |
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(Gk. for one giving rise to suffering) is any biologic agent that causes a disease in the host.
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Host |
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is any organism (or cell) harboring the pathogens that may (or may not in case of a strong immune response or depending upon the stage of infection) suffer from the disease.
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Peptide |
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is a molecule consisting of less than 50 repeating subunits called amino acids, which are in turn nitrogen-containing organic compounds. Smaller peptides are known as di-, tri- or tetra-peptides for two, three and four amino acids that constitute them, and henceforth. [1] Peptides with more than 10 amino acids are known as polypeptides. Usually peptides in multicellular organisms are derived from degradation of proteins outside or within the cells, or sometimes by their synthesis (production) within the body to serve various functions.
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Antigen |
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is any substance that can be recognized specifically by the cells or proteins of the immune system. These are most usually proteins. But, they can also be polysaccharides (polymers of sugars). This recognition occurs through the B cell receptor or the T cell receptor present respectively on B cells and T cells (see below). [3]
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Epitope |
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or antigenic determinant is a portion of a protein that can be recognized by the immune system. It consists of a single stretch of amino acids known as linear or sequential epitope, or widely separated amino acids or short stretches of amino acids that are brought close together because of three-dimensional protein-folding known as conformational or nonsequential epitope.
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Paratope |
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is that part of a protein molecule belonging to the immune system that specifically binds with the epitope. A paratope typically contains 15 to 22 amino acids.
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Phagocytosis |
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literally means cell eating which involves engulfing the whole of a small (at microscopic scale) particle through the formation of small projections of the cell known as pseudopodia literally meaning "false feet". This process is followed by degradation (breaking down into simpler molecules) of the engulfed entity (very often a pathogen). Any particle that is engulfed by phagocytosis is said to be "phagocytosed". [4]
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Actions of soluble antibodies [9] |
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Coat the pathogen not allowing it to adhere to the host cell • Precipitating (making the particles "sink" by attaching with them) the soluble antigens and promoting their clearance by other cells of immune system from the various tissues and blood • Coating the microorganisms to attract phagocytosing cells. This is known as opsonization. And thus the antibody acts as an opsonin • Activating the complement system • Marking up host cells infected by viruses for destruction in a process known as Antibody-dependent cell-mediated cytotoxicity (ADCC)
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