Polysialic-acid O-acetyltransferase

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In enzymology, a polysialic-acid O-acetyltransferase (EC 2.3.1.136) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an alpha-2,8-linked polymer of sialic acid CoA + polysialic acid acetylated on O-7 or O-9

Thus, the two substrates of this enzyme are acetyl-CoA and alpha-2,8-linked polymer of sialic acid, whereas its 3 products are CoA, polysialic acid acetylated on O-7, and polysialic acid acetylated on O-9.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:polysialic-acid O-acetyltransferase. Other names in common use include lecithin:retinol acyltransferase, lecithin-retinol acyltransferase, retinyl ester synthase, LRAT, and lecithin retinol acyl transferase.

[edit] References

• IUBMB entry for 2.3.1.136
• BRENDA references for 2.3.1.136 (Recommended.)
• PubMed references for 2.3.1.136
• PubMed Central references for 2.3.1.136
• Google Scholar references for 2.3.1.136
• Higa HH, Varki A (1988). "Acetyl-coenzyme A:polysialic acid O-acetyltransferase from K1-positive Escherichia coli. The enzyme responsible for the O-acetyl plus phenotype and for O-acetyl form variation". J. Biol. Chem. 263: 8872–8. PMID 2897964. 

[edit] External links

The CAS registry number for this enzyme class is 116412-21-6.

• IUBMB entry for 2.3.1.136

• KEGG entry for 2.3.1.136

• BRENDA entry for 2.3.1.136

• NiceZyme view of 2.3.1.136

• EC2PDB: PDB structures for 2.3.1.136

• PRIAM entry for 2.3.1.136

• PUMA2 entry for 2.3.1.136

• IntEnz: Integrated Enzyme entry for 2.3.1.136

• MetaCyc entry for 2.3.1.136

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050208: polysialic-acid O-acetyltransferase

• AMIGO entry for GO code 0050208: polysialic-acid O-acetyltransferase