POLR3F

From Wikipedia, the free encyclopedia

Polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa

PDB rendering based on 2dk5.

Available structures: 2dk5, 2dk8

Identifiers

Symbol(s)

POLR3F; MGC13517; RPC39; RPC6

External IDs

MGI: 1924086 HomoloGene: 4722

Gene ontology
Molecular Function:	• DNA binding • DNA-directed RNA polymerase activity • protein binding • transferase activity
Cellular Component:	• nucleus • DNA-directed RNA polymerase III complex
Biological Process:	• transcription • regulation of transcription from RNA polymerase III promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006466 (mRNA)
NP_006457 (protein)

NM_029763 (mRNA)
NP_084039 (protein)

Location

Chr 20: 18.4 - 18.41 Mb

Chr 2: 144.22 - 144.23 Mb

Pubmed search

[1]

[2]

Polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa, also known as POLR3F, is a human gene.^[1]

The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase.^[1]

[edit] References

^ ^a ^b Entrez Gene: POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa.

[edit] Further reading

Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hu P, Wu S, Sun Y, et al. (2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.". Mol. Cell. Biol. 22 (22): 8044-55. PMID 12391170.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Jones E, Kimura H, Vigneron M, et al. (2000). "Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III.". Exp. Cell Res. 254 (1): 163-72. doi:10.1006/excr.1999.4739. PMID 10623476.
Hsieh YJ, Kundu TK, Wang Z, et al. (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.". Mol. Cell. Biol. 19 (11): 7697-704. PMID 10523658.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Wang Z, Roeder RG (1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation.". Genes Dev. 11 (10): 1315-26. PMID 9171375.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.". J. Acquir. Immune Defic. Syndr. 5 (11): 1142-7. PMID 1403646.