POLR2A

From Wikipedia, the free encyclopedia

Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Identifiers

POLR2A; MGC75453; POLR2; POLRA; RPB1; RPBh1; RPO2; RPOL2; RpIILS; hRPB220; hsRPB1

External IDs

Gene ontology
Molecular Function:	• DNA binding • DNA-directed RNA polymerase activity • protein binding • zinc ion binding • transferase activity • metal ion binding
Cellular Component:	• nucleus • DNA-directed RNA polymerase II, core complex • nucleolus
Biological Process:	• transcription • transcription, DNA-dependent • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000937 (mRNA)
NP_000928 (protein)

NM_009089 (mRNA)
NP_033115 (protein)

Location

Chr 17: 7.33 - 7.36 Mb

Chr 11: 69.55 - 69.57 Mb

Pubmed search

[1]

[2]

Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa, also known as POLR2A, is a human gene.

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.^[1]

[edit] References

^ Entrez Gene: POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa.

[edit] Further reading

Jeang KT (1998). "Tat, Tat-associated kinase, and transcription.". J. Biomed. Sci. 5 (1): 24–7. PMID 9570510.
Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation.". Curr. Biol. 8 (13): R447–9. PMID 9651670.
Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression.". J. Cell. Biochem. 75 (3): 357–68. PMID 10536359.
Szentirmay MN, Sawadogo M (2000). "Spatial organization of RNA polymerase II transcription in the nucleus.". Nucleic Acids Res. 28 (10): 2019–25. PMID 10773068.
Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator.". IUBMB Life 51 (3): 175–81. PMID 11547919.