POLR1C

From Wikipedia, the free encyclopedia

Polymerase (RNA) I polypeptide C, 30kDa

Identifiers

POLR1C; RPA39; RPA40; RPA5; RPAC1

External IDs

OMIM: 610060 MGI: 103288 HomoloGene: 3586

Gene ontology
Molecular Function:	• DNA binding • DNA-directed RNA polymerase activity • transferase activity • protein dimerization activity
Cellular Component:	• nucleus • DNA-directed RNA polymerase I complex
Biological Process:	• transcription • transcription from RNA polymerase I promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004875 (mRNA)
NP_004866 (protein)

NM_009085 (mRNA)
NP_033111 (protein)

Location

Chr 6: 43.59 - 43.61 Mb

Chr 17: 45.71 - 45.71 Mb

Pubmed search

[1]

[2]

Polymerase (RNA) I polypeptide C, 30kDa, also known as POLR1C, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLR1C polymerase (RNA) I polypeptide C, 30kDa.

[edit] Further reading

Yao Y, Yamamoto K, Nishi Y, et al. (1997). "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III.". J. Biol. Chem. 271 (51): 32881-5. PMID 8955128.
Seither P, Zatsepina O, Hoffmann M, Grummt I (1997). "Constitutive and strong association of PAF53 with RNA polymerase I.". Chromosoma 106 (4): 216-25. PMID 9254723.
Dammann R, Pfeifer GP (1998). "Cloning and characterization of the human RNA polymerase I subunit hRPA40.". Biochim. Biophys. Acta 1396 (2): 153-7. PMID 9540830.
Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175-80. PMID 9653160.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298.
Shiratori M, Suzuki T, Itoh C, et al. (2002). "WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex.". Oncogene 21 (16): 2447-54. doi:10.1038/sj.onc.1205334. PMID 11971179.
Hu P, Wu S, Sun Y, et al. (2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.". Mol. Cell. Biol. 22 (22): 8044-55. PMID 12391170.
Dundr M, Hoffmann-Rohrer U, Hu Q, et al. (2002). "A kinetic framework for a mammalian RNA polymerase in vivo.". Science 298 (5598): 1623-6. doi:10.1126/science.1076164. PMID 12446911.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Yamamoto K, Yamamoto M, Hanada K, et al. (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription.". Mol. Cell. Biol. 24 (14): 6338-49. doi:10.1128/MCB.24.14.6338-6349.2004. PMID 15226435.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.