POLR1B

From Wikipedia, the free encyclopedia

Polymerase (RNA) I polypeptide B, 128kDa

Identifiers

POLR1B; FLJ10816; FLJ21921; MGC131780; RPA135; Rpo1-2

External IDs

OMIM: 602000 MGI: 108014 HomoloGene: 7133

Gene ontology
Molecular Function:	• DNA binding • DNA-directed RNA polymerase activity • protein binding • zinc ion binding • transferase activity • metal ion binding
Cellular Component:	• nucleus • nucleolus
Biological Process:	• transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_019014 (mRNA)
NP_061887 (protein)

NM_009086 (mRNA)
NP_033112 (protein)

Location

Chr 2: 113.02 - 113.05 Mb

Chr 2: 128.79 - 128.82 Mb

Pubmed search

[1]

[2]

Polymerase (RNA) I polypeptide B, 128kDa, also known as POLR1B, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLR1B polymerase (RNA) I polypeptide B, 128kDa.

[edit] Further reading

Seither P, Zatsepina O, Hoffmann M, Grummt I (1997). "Constitutive and strong association of PAF53 with RNA polymerase I.". Chromosoma 106 (4): 216-25. PMID 9254723.
Miller G, Panov KI, Friedrich JK, et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.". EMBO J. 20 (6): 1373-82. doi:10.1093/emboj/20.6.1373. PMID 11250903.
Seither P, Iben S, Thiry M, Grummt I (2002). "PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I.". Biol. Chem. 382 (8): 1163-70. PMID 11592397.
Shiau AK, Barstad D, Radek JT, et al. (2002). "Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.". Nat. Struct. Biol. 9 (5): 359-64. doi:10.1038/nsb787. PMID 11953755.
Egea PF, Mitschler A, Moras D (2002). "Molecular recognition of agonist ligands by RXRs.". Mol. Endocrinol. 16 (5): 987-97. PMID 11981034.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Yamamoto K, Yamamoto M, Hanada K, et al. (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription.". Mol. Cell. Biol. 24 (14): 6338-49. doi:10.1128/MCB.24.14.6338-6349.2004. PMID 15226435.
Philimonenko VV, Zhao J, Iben S, et al. (2005). "Nuclear actin and myosin I are required for RNA polymerase I transcription.". Nat. Cell Biol. 6 (12): 1165-72. doi:10.1038/ncb1190. PMID 15558034.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Zhang C, Comai L, Johnson DL (2005). "PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex.". Mol. Cell. Biol. 25 (16): 6899-911. doi:10.1128/MCB.25.16.6899-6911.2005. PMID 16055704.
Percipalle P, Fomproix N, Cavellán E, et al.. "The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.". EMBO Rep. 7 (5): 525-30. doi:10.1038/sj.embor.7400657. PMID 16514417.
Panova TB, Panov KI, Russell J, Zomerdijk JC (2006). "Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription.". Mol. Cell. Biol. 26 (16): 5957-68. doi:10.1128/MCB.00673-06. PMID 16880508.
Johnson SS, Zhang C, Fromm J, et al. (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.". Mol. Cell 26 (3): 367-79. doi:10.1016/j.molcel.2007.03.021. PMID 17499043.