POLK

From Wikipedia, the free encyclopedia

Polymerase (DNA directed) kappa

PDB rendering based on 1t94.

Available structures: 1t94, 2oh2

Identifiers

Symbol(s)

POLK; POLQ; DINB1; DINP

External IDs

OMIM: 605650 MGI: 1349767 HomoloGene: 32140

Gene ontology
Molecular Function:	• magnesium ion binding • DNA binding • DNA-directed DNA polymerase activity • zinc ion binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• DNA replication • mutagenesis • DNA repair

Orthologs

Human

Mouse

Refseq

NM_016218 (mRNA)
NP_057302 (protein)

NM_012048 (mRNA)
NP_036178 (protein)

Location

Chr 5: 74.84 - 74.93 Mb

Chr 13: 97.58 - 97.64 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed) kappa, also known as POLK, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLK Polymerase (DNA directed) kappa.

[edit] Further reading

Bavoux C, Hoffmann JS, Cazaux C (2005). "Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa.". Biochimie 87 (7): 637–46. doi:10.1016/j.biochi.2005.02.007. PMID 15989980.
Gerlach VL, Aravind L, Gotway G, et al. (1999). "Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11922–7. PMID 10518552.
Ogi T, Kato T, Kato T, Ohmori H (2000). "Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB.". Genes Cells 4 (11): 607–18. PMID 10620008.
Johnson RE, Prakash S, Prakash L (2000). "The human DINB1 gene encodes the DNA polymerase Poltheta.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3838–43. PMID 10760255.
Ohashi E, Ogi T, Kusumoto R, et al. (2000). "Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa.". Genes Dev. 14 (13): 1589–94. PMID 10887153.
Gerlach VL, Feaver WJ, Fischhaber PL, Friedberg EC (2001). "Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene.". J. Biol. Chem. 276 (1): 92–8. doi:10.1074/jbc.M004413200. PMID 11024016.
Haracska L, Unk I, Johnson RE, et al. (2002). "Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.". Mol. Cell. Biol. 22 (3): 784–91. PMID 11784855.
Washington MT, Johnson RE, Prakash L, Prakash S (2002). "Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini.". Proc. Natl. Acad. Sci. U.S.A. 99 (4): 1910–4. doi:10.1073/pnas.032594399. PMID 11842189.
Suzuki N, Ohashi E, Kolbanovskiy A, et al. (2002). "Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene).". Biochemistry 41 (19): 6100–6. PMID 11994005.
Fischhaber PL, Gerlach VL, Feaver WJ, et al. (2002). "Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides.". J. Biol. Chem. 277 (40): 37604–11. doi:10.1074/jbc.M206027200. PMID 12145297.
Bergoglio V, Bavoux C, Verbiest V, et al. (2003). "Localisation of human DNA polymerase kappa to replication foci.". J. Cell. Sci. 115 (Pt 23): 4413–8. PMID 12414988.
Haracska L, Prakash L, Prakash S (2003). "Role of human DNA polymerase kappa as an extender in translesion synthesis.". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16000–5. doi:10.1073/pnas.252524999. PMID 12444249.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wolfle WT, Washington MT, Prakash L, Prakash S (2003). "Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions.". Genes Dev. 17 (17): 2191–9. doi:10.1101/gad.1108603. PMID 12952891.
Haracska L, Prakash L, Prakash S (2003). "A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair.". Genes Dev. 17 (22): 2777–85. doi:10.1101/gad.1146103. PMID 14630940.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki N, Itoh S, Poon K, et al. (2004). "Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa.". Biochemistry 43 (20): 6304–11. doi:10.1021/bi0360298. PMID 15147214.
Ohashi E, Murakumo Y, Kanjo N, et al. (2005). "Interaction of hREV1 with three human Y-family DNA polymerases.". Genes Cells 9 (6): 523–31. doi:10.1111/j.1356-9597.2004.00747.x. PMID 15189446.
Washington MT, Minko IG, Johnson RE, et al. (2004). "Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa.". Mol. Cell. Biol. 24 (13): 5687–93. doi:10.1128/MCB.24.13.5687-5693.2004. PMID 15199127.
Uljon SN, Johnson RE, Edwards TA, et al. (2005). "Crystal structure of the catalytic core of human DNA polymerase kappa.". Structure 12 (8): 1395–404. doi:10.1016/j.str.2004.05.011. PMID 15296733.