POLE

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), epsilon

Identifiers

POLE; DKFZp434F222; FLJ21434; POLE1

External IDs

OMIM: 174762 MGI: 1196391 HomoloGene: 4539

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • chromatin binding • DNA-directed DNA polymerase activity • epsilon DNA polymerase activity • protein binding • zinc ion binding • 3'-5' exonuclease activity • transferase activity • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• G1/S transition of mitotic cell cycle • DNA synthesis during DNA repair • DNA replication

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006231 (mRNA)
NP_006222 (protein)

NM_011132 (mRNA)
NP_035262 (protein)

Location

Chr 12: 131.71 - 131.92 Mb

Chr 5: 110.53 - 110.58 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), epsilon, also known as POLE, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLE polymerase (DNA directed), epsilon.

[edit] Further reading

Popanda O, Thielmann HW (1992). "The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts.". Biochim. Biophys. Acta 1129 (2): 155-60. PMID 1730053.
Szpirer J, Pedeutour F, Kesti T, et al. (1994). "Localization of the gene for DNA polymerase epsilon (POLE) to human chromosome 12q24.3 and rat chromosome 12 by somatic cell hybrid panels and fluorescence in situ hybridization.". Genomics 20 (2): 223-6. PMID 8020968.
Kesti T, Frantti H, Syväoja JE (1993). "Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon.". J. Biol. Chem. 268 (14): 10238-45. PMID 8486689.
Mozzherin DJ, Fisher PA (1996). "Human DNA polymerase epsilon: enzymologic mechanism and gap-filling synthesis.". Biochemistry 35 (11): 3572-7. doi:10.1021/bi952142p. PMID 8639508.
Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817-23. PMID 9121429.
Coll JM, Hickey RJ, Cronkey EA, et al. (1998). "Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome.". Oncol. Res. 9 (11-12): 629-39. PMID 9563011.
Huang D, Pospiech H, Kesti T, Syväoja JE (1999). "Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon.". Biochem. J. 339 ( Pt 3): 657-65. PMID 10215605.
Araújo SJ, Tirode F, Coin F, et al. (2000). "Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK.". Genes Dev. 14 (3): 349-59. PMID 10673506.
Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.". J. Biol. Chem. 275 (30): 23247-52. doi:10.1074/jbc.M002548200. PMID 10801849.
Mäkiniemi M, Hillukkala T, Tuusa J, et al. (2001). "BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.". J. Biol. Chem. 276 (32): 30399-406. doi:10.1074/jbc.M102245200. PMID 11395493.
Fuss J, Linn S (2002). "Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication late, but not early, in S phase.". J. Biol. Chem. 277 (10): 8658-66. doi:10.1074/jbc.M110615200. PMID 11741962.
Ohta S, Shiomi Y, Sugimoto K, et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.". J. Biol. Chem. 277 (43): 40362-7. doi:10.1074/jbc.M206194200. PMID 12171929.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon.". Nucleic Acids Res. 31 (19): 5568-75. PMID 14500819.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.". Science 302 (5652): 1960-3. doi:10.1126/science.1088821. PMID 14671302.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Rytkönen AK, Vaara M, Nethanel T, et al. (2006). "Distinctive activities of DNA polymerases during human DNA replication.". FEBS J. 273 (13): 2984-3001. doi:10.1111/j.1742-4658.2006.05310.x. PMID 16762037.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.