POLE3

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), epsilon 3 (p17 subunit)

Identifiers

POLE3; CHARAC17; CHRAC17; YBL1; p17

External IDs

OMIM: 607267 MGI: 1933378 HomoloGene: 9694

Gene ontology
Molecular Function:	• epsilon DNA polymerase activity • protein binding • transferase activity • sequence-specific DNA binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• DNA replication

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017443 (mRNA)
NP_059139 (protein)

NM_021498 (mRNA)
NP_067473 (protein)

Location

Chr 9: 115.21 - 115.21 Mb

Chr 4: 62.01 - 62.01 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), epsilon 3 (p17 subunit), also known as POLE3, is a human gene.^[1]

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit).

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
Poot RA, Dellaire G, Hülsmann BB, et al. (2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMID 10880450.
Bolognese F, Imbriano C, Caretti G, Mantovani R (2000). "Cloning and characterization of the histone-fold proteins YBL1 and YCL1.". Nucleic Acids Res. 28 (19): 3830–8. PMID 11000277.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon.". Nucleic Acids Res. 31 (19): 5568–75. PMID 14500819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.