POLD3

From Wikipedia, the free encyclopedia

Polymerase (DNA-directed), delta 3, accessory subunit

Identifiers

POLD3; KIAA0039; MGC119642; MGC119643; P66; P68

External IDs

MGI: 1915217 HomoloGene: 38202

Gene ontology
Molecular Function:	• DNA binding • delta DNA polymerase activity • transferase activity
Cellular Component:	• nucleus • delta DNA polymerase complex
Biological Process:	• DNA synthesis during DNA repair • mismatch repair

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006591 (mRNA)
NP_006582 (protein)

NM_133692 (mRNA)
NP_598453 (protein)

Location

Chr 11: 73.98 - 74.03 Mb

Chr 7: 99.96 - 100 Mb

Pubmed search

[1]

[2]

Polymerase (DNA-directed), delta 3, accessory subunit, also known as POLD3, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit.

[edit] Further reading

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27–35. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. PMID 7584028.
Zeng XR, Jiang Y, Zhang SJ, et al. (1994). "DNA polymerase delta is involved in the cellular response to UV damage in human cells.". J. Biol. Chem. 269 (19): 13748–51. PMID 7910606.
Longley MJ, Pierce AJ, Modrich P (1997). "DNA polymerase delta is required for human mismatch repair in vitro.". J. Biol. Chem. 272 (16): 10917–21. PMID 9099749.
Hughes P, Tratner I, Ducoux M, et al. (1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts.". Nucleic Acids Res. 27 (10): 2108–14. PMID 10219083.
Mo J, Liu L, Leon A, et al. (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA.". Biochemistry 39 (24): 7245–54. PMID 10852724.
Ducoux M, Urbach S, Baldacci G, et al. (2002). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.". J. Biol. Chem. 276 (52): 49258–66. doi:10.1074/jbc.M106990200. PMID 11595739.
Ohta S, Shiomi Y, Sugimoto K, et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Pohler JR, Otterlei M, Warbrick E (2006). "An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit.". BMC Mol. Biol. 6: 17. doi:10.1186/1471-2199-6-17. PMID 16000169.
Takemura M, Yoshida S, Akiyama T, et al. (2006). "Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase.". Biochim. Biophys. Acta 1764 (9): 1447–53. doi:10.1016/j.bbapap.2006.06.015. PMID 16935576.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Masuda Y, Suzuki M, Piao J, et al. (2007). "Dynamics of human replication factors in the elongation phase of DNA replication.". Nucleic Acids Res. 35 (20): 6904–16. doi:10.1093/nar/gkm822. PMID 17932049.