POLA2

From Wikipedia, the free encyclopedia

Polymerase (DNA directed), alpha 2 (70kD subunit)

Identifiers

POLA2; FLJ21662; FLJ37250

External IDs

Gene ontology
Molecular Function:	• molecular_function • DNA binding • DNA-directed DNA polymerase activity • protein binding • protein heterodimerization activity
Cellular Component:	• nucleus • alpha DNA polymerase:primase complex
Biological Process:	• protein import into nucleus, translocation • DNA replication

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002689 (mRNA)
NP_002680 (protein)

NM_008893 (mRNA)
NP_032919 (protein)

Location

Chr 11: 64.79 - 64.82 Mb

Chr 19: 5.94 - 5.96 Mb

Pubmed search

[1]

[2]

Polymerase (DNA directed), alpha 2 (70kD subunit), also known as POLA2, is a human gene.^[1]

[edit] References

^ Entrez Gene: POLA2 polymerase (DNA directed), alpha 2 (70kD subunit).

[edit] Further reading

Pollok S, Stoepel J, Bauerschmidt C, et al. (2003). "Regulation of eukaryotic DNA replication at the initiation step.". Biochem. Soc. Trans. 31 (Pt 1): 266–9. doi:10.1042/. PMID 12546699.
Nasheuer HP, Moore A, Wahl AF, Wang TS (1991). "Cell cycle-dependent phosphorylation of human DNA polymerase alpha.". J. Biol. Chem. 266 (12): 7893–903. PMID 1902230.
Collins KL, Russo AA, Tseng BY, Kelly TJ (1993). "The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication.". EMBO J. 12 (12): 4555–66. PMID 8223465.
Dantzer F, Nasheuer HP, Vonesch JL, et al. (1998). "Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication.". Nucleic Acids Res. 26 (8): 1891–8. PMID 9518481.
Schneider A, Smith RW, Kautz AR, et al. (1998). "Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit.". J. Biol. Chem. 273 (34): 21608–15. PMID 9705292.
Huang D, Jokela M, Tuusa J, et al. (2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase epsilon B-subunit gene POLE2.". Nucleic Acids Res. 29 (13): 2810–21. PMID 11433027.
Taneja P, Gu J, Peng R, et al. (2002). "A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication.". J. Biol. Chem. 277 (43): 40853–61. doi:10.1074/jbc.M208067200. PMID 12181327.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.