PNPO

From Wikipedia, the free encyclopedia


Pyridoxamine 5'-phosphate oxidase
PDB rendering based on 1nrg.
Available structures: 1nrg
Identifiers
Symbol(s) PNPO; FLJ10535; PDXPO
External IDs OMIM: 603287 MGI: 2144151 HomoloGene: 5364
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55163 103711
Ensembl ENSG00000108439 ENSMUSG00000018659
Uniprot Q9NVS9 Q3TP70
Refseq NM_018129 (mRNA)
NP_060599 (protein)		 NM_134021 (mRNA)
NP_598782 (protein)
Location Chr 17: 43.37 - 43.38 Mb Chr 11: 96.75 - 96.76 Mb
Pubmed search [1] [2]

Pyridoxamine 5'-phosphate oxidase, also known as PNPO, is a human gene.[1]

Vitamin B6, or pyridoxal 5-prime-phosphate (PLP), is critical for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. The rate-limiting enzyme in vitamin B6 synthesis is pyridoxine-5-prime-phosphate (PNP) oxidase (PNPO; EC 1.4.3.5).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: PNPO pyridoxamine 5'-phosphate oxidase.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Ngo EO, LePage GR, Thanassi JW, et al. (1998). "Absence of pyridoxine-5'-phosphate oxidase (PNPO) activity in neoplastic cells: isolation, characterization, and expression of PNPO cDNA.". Biochemistry 37 (21): 7741-8. doi:10.1021/bi972983r. PMID 9601034. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Musayev FN, Di Salvo ML, Ko TP, et al. (2004). "Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase.". Protein Sci. 12 (7): 1455-63. PMID 12824491. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Kang JH, Hong ML, Kim DW, et al. (2004). "Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase.". Eur. J. Biochem. 271 (12): 2452-61. doi:10.1111/j.1432-1033.2004.04175.x. PMID 15182361. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Mills PB, Surtees RA, Champion MP, et al. (2005). "Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase.". Hum. Mol. Genet. 14 (8): 1077-86. doi:10.1093/hmg/ddi120. PMID 15772097. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
 This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.