PLDN

From Wikipedia, the free encyclopedia

Pallidin homolog (mouse)

Identifiers

PLDN; PA; PALLID

External IDs

OMIM: 604310 MGI: 1927580 HomoloGene: 40841

Gene ontology
Molecular Function:	• syntaxin-13 binding • identical protein binding
Cellular Component:	• cellular_component • endosome • membrane
Biological Process:	• membrane fusion • synaptic vesicle docking during exocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012388 (mRNA)
NP_036520 (protein)

NM_019788 (mRNA)
NP_062762 (protein)

Location

Chr 15: 43.67 - 43.69 Mb

Chr 2: 122.43 - 122.44 Mb

Pubmed search

[1]

[2]

Pallidin homolog (mouse), also known as PLDN, is a human gene.^[1]

The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: PLDN pallidin homolog (mouse).

[edit] Further reading

Falcón-Pérez JM, Dell'Angelica EC (2002). "The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis.". Pigment Cell Res. 15 (2): 82–6. PMID 11936273.
Korsgren C, Cohen CM (1988). "Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3.". J. Biol. Chem. 263 (21): 10212–8. PMID 2968981.
Azim AC, Marfatia SM, Korsgren C, et al. (1996). "Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins.". Biochemistry 35 (9): 3001–6. doi:10.1021/bi951745y. PMID 8608138.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Risinger MA, Korsgren C, Cohen CM (1997). "Role of N-myristylation in targeting of band 4.2 (pallidin) in nonerythroid cells.". Exp. Cell Res. 229 (2): 421–31. doi:10.1006/excr.1996.0387. PMID 8986625.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Huang L, Kuo YM, Gitschier J (1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency.". Nat. Genet. 23 (3): 329–32. doi:10.1038/15507. PMID 10610180.
Falcón-Pérez JM, Starcevic M, Gautam R, Dell'Angelica EC (2002). "BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules.". J. Biol. Chem. 277 (31): 28191–9. doi:10.1074/jbc.M204011200. PMID 12019270.
Moriyama K, Bonifacino JS (2003). "Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles.". Traffic 3 (9): 666–77. PMID 12191018.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ciciotte SL, Gwynn B, Moriyama K, et al. (2003). "Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1).". Blood 101 (11): 4402–7. doi:10.1182/blood-2003-01-0020. PMID 12576321.
Li W, Zhang Q, Oiso N, et al. (2003). "Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).". Nat. Genet. 35 (1): 84–9. doi:10.1038/ng1229. PMID 12923531.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Starcevic M, Dell'Angelica EC (2004). "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).". J. Biol. Chem. 279 (27): 28393–401. doi:10.1074/jbc.M402513200. PMID 15102850.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.