PLCB3

From Wikipedia, the free encyclopedia

Phospholipase C, beta 3 (phosphatidylinositol-specific)

Identifiers

External IDs

OMIM: 600230 MGI: 104778 HomoloGene: 47960

Gene ontology
Molecular Function:	• phosphoinositide phospholipase C activity • signal transducer activity • calcium ion binding • hydrolase activity
Cellular Component:	• membrane
Biological Process:	• lipid metabolic process • intracellular signaling cascade • lipid catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000932 (mRNA)
NP_000923 (protein)

NM_008874 (mRNA)
NP_032900 (protein)

Location

Chr 11: 63.78 - 63.79 Mb

Chr 19: 7.02 - 7.04 Mb

Pubmed search

[1]

[2]

Phospholipase C, beta 3 (phosphatidylinositol-specific), also known as PLCB3, is a human gene.^[1]

[edit] References

^ Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific).

[edit] Further reading

Carozzi AJ, Kriz RW, Webster C, Parker PJ (1993). "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily.". Eur. J. Biochem. 210 (2): 521–9. PMID 1333955.
Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. PMID 1979339.
Zauli G, Previati M, Caramelli E, et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.". Eur. J. Immunol. 25 (9): 2695–700. PMID 7589147.
Lagercrantz J, Carson E, Phelan C, et al. (1995). "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3).". Genomics 26 (3): 467–72. PMID 7607669.
Mazuruk K, Schoen TJ, Chader GJ, Rodriguez IR (1995). "Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene.". Biochem. Biophys. Res. Commun. 212 (1): 190–5. doi:10.1006/bbrc.1995.1955. PMID 7612006.
Sinke RJ, Geurts van Kessel AG (1995). "Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13.". Genomics 25 (2): 568–9. PMID 7789993.
Weber G, Friedman E, Grimmond S, et al. (1995). "The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours.". Hum. Mol. Genet. 3 (10): 1775–81. PMID 7849701.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. PMID 9278385.
Snow BE, Hall RA, Krumins AM, et al. (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.". J. Biol. Chem. 273 (28): 17749–55. PMID 9651375.
Wang S, Zhou Y, Lukinius A, et al. (1998). "Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3.". Biochim. Biophys. Acta 1393 (1): 173–8. PMID 9714794.
Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3-4): 184–92. PMID 9730685.
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.". J. Neurochem. 73 (4): 1363–74. PMID 10501179.
Hwang JI, Heo K, Shin KJ, et al. (2000). "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2.". J. Biol. Chem. 275 (22): 16632–7. doi:10.1074/jbc.M001410200. PMID 10748023.
Wang JC, Waltner-Law M, Yamada K, et al. (2000). "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.". J. Biol. Chem. 275 (24): 18418–23. doi:10.1074/jbc.M910211199. PMID 10748198.
Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. PMID 10843712.
Caricasole A, Sala C, Roncarati R, et al. (2001). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).". Biochim. Biophys. Acta 1517 (1): 63–72. PMID 11118617.
Stålberg P, Lopez-Egido JR, Wang S, et al. (2001). "Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene.". Biochem. Biophys. Res. Commun. 281 (1): 227–31. doi:10.1006/bbrc.2001.4329. PMID 11178984.
Xia C, Bao Z, Yue C, et al. (2001). "Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases.". J. Biol. Chem. 276 (23): 19770–7. doi:10.1074/jbc.M006266200. PMID 11278298.
Yue C, Sanborn BM (2001). "KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.". Mol. Cell. Endocrinol. 175 (1-2): 149–56. PMID 11325525.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.". Virology 303 (1): 174–80. PMID 12482669.