Platelet-activating factor acetyltransferase

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In enzymology, a platelet-activating factor acetyltransferase (EC 2.3.1.149) is an enzyme that catalyzes the chemical reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid $\rightleftharpoons$ 1-organyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-acetyl-sn-glycero-3-phospholipid

Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine and 1-organyl-2-lyso-sn-glycero-3-phospholipid, whereas its two products are 1-organyl-2-lyso-sn-glycero-3-phosphocholine and 1-alkyl-2-acetyl-sn-glycero-3-phospholipid.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glyce ro-3-phospholipid acetyltransferase. This enzyme is also called PAF acetyltransferase.

[edit] References

IUBMB entry for 2.3.1.149
BRENDA references for 2.3.1.149 (Recommended.)
PubMed references for 2.3.1.149
PubMed Central references for 2.3.1.149
Google Scholar references for 2.3.1.149
Lee TC, Uemura Y, Snyder F (1992). "A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor (PAF) with PAF as the acetate donor in HL-60 cells". J. Biol. Chem. 267: 19992–20001. PMID 1400315.