PLAU

From Wikipedia, the free encyclopedia

Plasminogen activator, urokinase

PDB rendering based on 1c5w.

Available structures: 1c5w, 1c5x, 1c5y, 1c5z, 1ejn, 1f5k, 1f5l, 1f92, 1fv9, 1gi7, 1gi8, 1gi9, 1gj7, 1gj8, 1gj9, 1gja, 1gjb, 1gjc, 1gjd, 1kdu, 1lmw, 1o3p, 1o5a, 1o5b, 1o5c, 1owd, 1owe, 1owh, 1owi, 1owj, 1owk, 1sc8, 1sqa, 1sqo, 1sqt, 1u6q, 1urk, 1vj9, 1vja, 2fd6, 2i9a, 2i9b

Identifiers

Symbol(s)

PLAU; ATF; UPA; URK; u-PA

External IDs

OMIM: 191840 MGI: 97611 HomoloGene: 55670

Gene ontology
Molecular Function:	• serine-type endopeptidase activity • peptidase activity • plasminogen activator activity • kinase activity
Cellular Component:	• extracellular space
Biological Process:	• proteolysis • chemotaxis • signal transduction • blood coagulation • fibrinolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002658 (mRNA)
NP_002649 (protein)

NM_008873 (mRNA)
NP_032899 (protein)

Location

Chr 10: 75.34 - 75.35 Mb

Chr 14: 19.63 - 19.63 Mb

Pubmed search

[1]

[2]

Plasminogen activator, urokinase, also known as PLAU, is a human gene.

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.^[1]

[edit] References

^ Entrez Gene: PLAU plasminogen activator, urokinase.

[edit] Further reading

Ploug M, Gårdsvoll H, Jørgensen TJ, et al. (2002). "Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy.". Biochem. Soc. Trans. 30 (2): 177–83. doi:10.1042/. PMID 12023847.
Alfano M, Sidenius N, Blasi F, Poli G (2004). "The role of urokinase-type plasminogen activator (uPA)/uPA receptor in HIV-1 infection.". J. Leukoc. Biol. 74 (5): 750–6. doi:10.1189/jlb.0403176. PMID 12960238.
Harbeck N, Kates RE, Gauger K, et al. (2004). "Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer.". Thromb. Haemost. 91 (3): 450–6. doi:10.1160/TH03-12-0798. PMID 14983219.
Gilabert-Estelles J, Ramon LA, España F, et al. (2006). "Expression of the fibrinolytic components in endometriosis.". Pathophysiol. Haemost. Thromb. 35 (1-2): 136–40. doi:10.1159/000093556. PMID 16855359.