PKIG

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Protein kinase (cAMP-dependent, catalytic) inhibitor gamma
Identifiers
Symbol(s) PKIG; MGC126458; MGC126459
External IDs OMIM: 604932 MGI: 1343086 HomoloGene: 5133
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 11142 18769
Ensembl ENSG00000168734 n/a
Uniprot Q9Y2B9 n/a
Refseq NM_007066 (mRNA)
NP_008997 (protein)		 NM_001039390 (mRNA)
NP_001034479 (protein)
Location Chr 20: 42.59 - 42.69 Mb n/a
Pubmed search [1] [2]

Protein kinase (cAMP-dependent, catalytic) inhibitor gamma, also known as PKIG, is a human gene.[1]

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma.

[edit] Further reading

  • Collins SP, Uhler MD (1997). "Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase.". J. Biol. Chem. 272 (29): 18169-78. PMID 9218452. 
  • Zheng L, Yu L, Tu Q, et al. (2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA.". Biochem. J. 349 (Pt 2): 403-7. PMID 10880337. 
  • Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20.". Genomics 76 (1-3): 45-57. doi:10.1006/geno.2001.6584. PMID 11549316. 
  • Lum H, Hao Z, Gayle D, et al. (2002). "Vascular endothelial cells express isoforms of protein kinase A inhibitor.". Am. J. Physiol., Cell Physiol. 282 (1): C59-66. doi:10.1152/ajpcell.00256.2001. PMID 11742798. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
  • Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors.". Brain Res. Mol. Brain Res. 99 (2): 145-9. PMID 11978406. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zhao L, Yang S, Zhou GQ, et al. (2006). "Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation.". Int. J. Biochem. Cell Biol. 38 (12): 2064-73. doi:10.1016/j.biocel.2006.05.015. PMID 16870489. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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