PIR (gene)

From Wikipedia, the free encyclopedia

Pirin (iron-binding nuclear protein)

PDB rendering based on 1j1l.

Available structures: 1j1l

Identifiers

Symbol(s)

PIR;

External IDs

OMIM: 603329 MGI: 1916906 HomoloGene: 2717

Gene ontology
Molecular Function:	• transcription cofactor activity • iron ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001018109 (mRNA)
NP_001018119 (protein)

NM_027153 (mRNA)
NP_081429 (protein)

Location

Chr X: 15.31 - 15.42 Mb

Chr X: 159.61 - 159.72 Mb

Pubmed search

[1]

[2]

Pirin (iron-binding nuclear protein), also known as PIR, is a human gene.^[1]

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: PIR pirin (iron-binding nuclear protein).

[edit] Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Adams M, Jia Z (2005). "Structural and biochemical analysis reveal pirins to possess quercetinase activity.". J. Biol. Chem. 280 (31): 28675-82. doi:10.1074/jbc.M501034200. PMID 15951572.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Pang H, Bartlam M, Zeng Q, et al. (2004). "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.". J. Biol. Chem. 279 (2): 1491-8. doi:10.1074/jbc.M310022200. PMID 14573596.
Zeng Q, Li X, Bartlam M, et al. (2004). "Purification, crystallization and preliminary X-ray analysis of human pirin.". Acta Crystallogr. D Biol. Crystallogr. 59 (Pt 8): 1496-8. PMID 12876364.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dechend R, Hirano F, Lehmann K, et al. (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.". Oncogene 18 (22): 3316-23. doi:10.1038/sj.onc.1202717. PMID 10362352.
Wendler WM, Kremmer E, Förster R, Winnacker EL (1997). "Identification of pirin, a novel highly conserved nuclear protein.". J. Biol. Chem. 272 (13): 8482-9. PMID 9079676.