PINX1

From Wikipedia, the free encyclopedia

PIN2-interacting protein 1

Identifiers

PINX1; FLJ20565; LPTL; LPTS; MGC8850

External IDs

OMIM: 606505 MGI: 1919650 HomoloGene: 31531

Gene ontology
Molecular Function:	• molecular_function • nucleic acid binding • protein binding
Cellular Component:	• chromosome, telomeric region • cellular_component • intracellular • nucleus • chromosome • nucleolus
Biological Process:	• telomere maintenance via telomerase • cell cycle • negative regulation of cell proliferation • negative regulation of progression through cell cycle

Orthologs

Human

Mouse

Refseq

NM_017884 (mRNA)
NP_060354 (protein)

NM_028228 (mRNA)
NP_082504 (protein)

Location

Chr 8: 10.66 - 10.73 Mb

Chr 14: 62.81 - 62.87 Mb

Pubmed search

[1]

[2]

PIN2-interacting protein 1, also known as PINX1, is a human gene.^[1]

[edit] References

^ Entrez Gene: PINX1 PIN2-interacting protein 1.

[edit] Further reading

Liao C, Zhao M, Song H, et al. (2000). "Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma.". Hepatology 32 (4 Pt 1): 721–7. doi:10.1053/jhep.2000.17967. PMID 11003615.
Zhou XZ, Lu KP (2001). "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.". Cell 107 (3): 347–59. PMID 11701125.
Guglielmi B, Werner M (2002). "The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition.". J. Biol. Chem. 277 (38): 35712–9. doi:10.1074/jbc.M205526200. PMID 12107183.
Liao C, Zhao MJ, Zhao J, et al. (2003). "Over-expression of LPTS-L in hepatocellular carcinoma cell line SMMC-7721 induces crisis.". World J. Gastroenterol. 8 (6): 1050–2. PMID 12439923.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Liao C, Zhao MJ, Zhao J, et al. (2003). "Mutation analysis of novel human liver-related putative tumor suppressor gene in hepatocellular carcinoma.". World J. Gastroenterol. 9 (1): 89–93. PMID 12508358.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wang S, Liao C, Li T, Zhao M (2004). "Cloning and characterization of the promoter region of human LPTS/PinX1 gene.". Biochim. Biophys. Acta 1676 (3): 261–5. doi:10.1016/j.bbaexp.2003.12.002. PMID 14984932.
Song H, Li Y, Chen G, et al. (2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.". Biochem. Biophys. Res. Commun. 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. PMID 15044100.
Banik SS, Counter CM (2005). "Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR.". J. Biol. Chem. 279 (50): 51745–8. doi:10.1074/jbc.M408131200. PMID 15381700.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kondo T, Oue N, Mitani Y, et al. (2005). "Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma.". Oncogene 24 (1): 157–64. doi:10.1038/sj.onc.1207832. PMID 15637589.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.