PIM2 (gene)

From Wikipedia, the free encyclopedia

Pim-2 oncogene

PDB rendering based on 2iwi.

Available structures: 2iwi

Identifiers

Symbol(s)

PIM2;

External IDs

OMIM: 300295 MGI: 97587 HomoloGene: 17098

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • anti-apoptosis • male meiosis • cell proliferation • apoptotic mitochondrial changes

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006875 (mRNA)
NP_006866 (protein)

XM_977259 (mRNA)
XP_982353 (protein)

Location

Chr X: 48.66 - 48.66 Mb

n/a

Pubmed search

[1]

[2]

Pim-2 oncogene, also known as PIM2, is a human gene.^[1]

[edit] References

^ Entrez Gene: PIM2 pim-2 oncogene.

[edit] Further reading

Baytel D, Shalom S, Madgar I, et al. (1998). "The human Pim-2 proto-oncogene and its testicular expression.". Biochim. Biophys. Acta 1442 (2-3): 274-85. PMID 9804974.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yan B, Zemskova M, Holder S, et al. (2003). "The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death.". J. Biol. Chem. 278 (46): 45358-67. doi:10.1074/jbc.M307933200. PMID 12954615.
Cohen AM, Grinblat B, Bessler H, et al. (2004). "Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma.". Leuk. Lymphoma 45 (5): 951-5. PMID 15291354.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hammerman PS, Fox CJ, Cinalli RM, et al. (2005). "Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation.". Cancer Res. 64 (22): 8341-8. doi:10.1158/0008-5472.CAN-04-2284. PMID 15548703.
Rainio EM, Ahlfors H, Carter KL, et al. (2005). "Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity.". Virology 333 (2): 201-6. doi:10.1016/j.virol.2005.01.001. PMID 15721354.
Dai H, Li R, Wheeler T, et al. (2005). "Pim-2 upregulation: biological implications associated with disease progression and perinueral invasion in prostate cancer.". Prostate 65 (3): 276-86. doi:10.1002/pros.20294. PMID 16015593.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Macdonald A, Campbell DG, Toth R, et al. (2006). "Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.". BMC Cell Biol. 7: 1. doi:10.1186/1471-2121-7-1. PMID 16403219.