PIK3R2

From Wikipedia, the free encyclopedia

Phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)

Identifiers

PIK3R2; P85B; p85-BETA

External IDs

OMIM: 603157 MGI: 1098772 HomoloGene: 3687

Gene ontology
Molecular Function:	• protein binding • 1-phosphatidylinositol-3-kinase activity • phosphoinositide 3-kinase regulator activity
Cellular Component:	• intracellular • phosphoinositide 3-kinase complex
Biological Process:	• intracellular signaling cascade • insulin receptor signaling pathway • negative regulation of anti-apoptosis • regulation of phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005027 (mRNA)
NP_005018 (protein)

NM_008841 (mRNA)
NP_032867 (protein)

Location

Chr 19: 18.13 - 18.14 Mb

Chr 8: 73.7 - 73.71 Mb

Pubmed search

[1]

[2]

Phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta), also known as PIK3R2, is a human gene.^[1]

[edit] References

^ Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta).

[edit] Further reading

Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.
Volinia S, Patracchini P, Otsu M, et al. (1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta.". Oncogene 7 (4): 789–93. PMID 1314371.
Gout I, Dhand R, Panayotou G, et al. (1993). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.". Biochem. J. 288 ( Pt 2): 395–405. PMID 1334406.
Carpenter CL, Duckworth BC, Auger KR, et al. (1991). "Purification and characterization of phosphoinositide 3-kinase from rat liver.". J. Biol. Chem. 265 (32): 19704–11. PMID 2174051.
Truitt KE, Hicks CM, Imboden JB (1994). "Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.". J. Exp. Med. 179 (3): 1071–6. PMID 7509360.
Herbst R, Shearman MS, Jallal B, et al. (1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro.". Biochemistry 34 (17): 5971–9. PMID 7537096.
Craparo A, O'Neill TJ, Gustafson TA (1995). "Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.". J. Biol. Chem. 270 (26): 15639–43. PMID 7541045.
He W, O'Neill TJ, Gustafson TA (1995). "Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.". J. Biol. Chem. 270 (40): 23258–62. PMID 7559478.
Kapeller R, Toker A, Cantley LC, Carpenter CL (1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.". J. Biol. Chem. 270 (43): 25985–91. PMID 7592789.
Hartley D, Meisner H, Corvera S (1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl.". J. Biol. Chem. 270 (31): 18260–3. PMID 7629144.
Pandey A, Lazar DF, Saltiel AR, Dixit VM (1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.". J. Biol. Chem. 269 (48): 30154–7. PMID 7982920.
August A, Dupont B (1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase.". Int. Immunol. 6 (5): 769–74. PMID 8080844.
Fukazawa T, Miyake S, Band V, Band H (1996). "Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins.". J. Biol. Chem. 271 (24): 14554–9. PMID 8662998.
Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.". J. Biol. Chem. 271 (38): 22961–4. PMID 8798481.
Sattler M, Salgia R, Shrikhande G, et al. (1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL).". J. Biol. Chem. 272 (15): 10248–53. PMID 9092574.
Vanhaesebroeck B, Welham MJ, Kotani K, et al. (1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. PMID 9113989.
Briand G, Barbeau B, Tremblay M (1997). "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase.". Virology 228 (2): 171–9. doi:10.1006/viro.1996.8399. PMID 9123823.
Braunger J, Schleithoff L, Schulz AS, et al. (1997). "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.". Oncogene 14 (22): 2619–31. doi:10.1038/sj.onc.1201123. PMID 9178760.
Shepherd PR, Navé BT, Rincon J, et al. (1997). "Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.". J. Biol. Chem. 272 (30): 19000–7. PMID 9228082.
Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.". Eur. J. Immunol. 27 (9): 2457–65. PMID 9341793.