PIK3CG

From Wikipedia, the free encyclopedia

Phosphoinositide-3-kinase, catalytic, gamma polypeptide

PDB rendering based on 17eu.

Available structures: 1e7u, 1e7v, 1e8w, 1e8x, 1e8y, 1e8z, 1e90, 1he8, 2a4z, 2a5u, 2chw, 2chx, 2chz

Identifiers

Symbol(s)

PIK3CG; PI3K; PI3CG; PI3Kgamma; PIK3

External IDs

OMIM: 601232 MGI: 1353576 HomoloGene: 68269

Gene ontology
Molecular Function:	• inositol or phosphatidylinositol kinase activity • protein binding • 1-phosphatidylinositol-3-kinase activity • transferase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Cellular Component:	• phosphoinositide 3-kinase complex
Biological Process:	• protein amino acid phosphorylation • G-protein coupled receptor protein signaling pathway • negative regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002649 (mRNA)
NP_002640 (protein)

NM_020272 (mRNA)
NP_064668 (protein)

Location

Chr 7: 106.29 - 106.33 Mb

Chr 12: 32.76 - 32.79 Mb

Pubmed search

[1]

[2]

Phosphoinositide-3-kinase, catalytic, gamma polypeptide, also known as PIK3CG, is a human gene.

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.^[1]

[edit] See also

[edit] References

^ Entrez Gene: PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide.

[edit] Further reading

Alloatti G, Montrucchio G, Lembo G, Hirsch E (2004). "Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease.". Biochem. Soc. Trans. 32 (Pt 2): 383–6. doi:10.1042/. PMID 15046613.
Rommel C, Camps M, Ji H (2007). "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?". Nat. Rev. Immunol. 7 (3): 191–201. doi:10.1038/nri2036. PMID 17290298.