PIK3CD

From Wikipedia, the free encyclopedia

Phosphoinositide-3-kinase, catalytic, delta polypeptide

Identifiers

External IDs

OMIM: 602839 MGI: 1098211 HomoloGene: 3686

Gene ontology
Molecular Function:	• inositol or phosphatidylinositol kinase activity • 1-phosphatidylinositol-3-kinase activity • transferase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Cellular Component:	• phosphoinositide 3-kinase complex
Biological Process:	• protein amino acid phosphorylation • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005026 (mRNA)
NP_005017 (protein)

XM_986912 (mRNA)
XP_992006 (protein)

Location

Chr 1: 9.63 - 9.71 Mb

Chr 4: 148.49 - 148.54 Mb

Pubmed search

[1]

[2]

Phosphoinositide-3-kinase, catalytic, delta polypeptide, also known as PIK3CD, is a human gene.^[1]

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: PIK3CD phosphoinositide-3-kinase, catalytic, delta polypeptide.

[edit] Further reading

Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.
Rommel C, Camps M, Ji H (2007). "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?". Nat. Rev. Immunol. 7 (3): 191–201. doi:10.1038/nri2036. PMID 17290298.
Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.". J. Biol. Chem. 271 (38): 22961–4. PMID 8798481.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Vanhaesebroeck B, Welham MJ, Kotani K, et al. (1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. PMID 9113989.
Chantry D, Vojtek A, Kashishian A, et al. (1997). "p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.". J. Biol. Chem. 272 (31): 19236–41. PMID 9235916.
Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.". Eur. J. Immunol. 27 (9): 2457–65. PMID 9341793.
Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.". Eur. J. Immunol. 27 (11): 2805–11. PMID 9394803.
Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.". Biochem. Biophys. Res. Commun. 242 (2): 332–7. PMID 9446795.
Seki N, Nimura Y, Ohira M, et al. (1998). "Identification and chromosome assignment of a human gene encoding a novel phosphatidylinositol-3 kinase.". DNA Res. 4 (5): 355–8. PMID 9455486.
Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.". AIDS 12 (11): 1275–84. PMID 9708406.
Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.". Eur. J. Immunol. 28 (10): 3183–91. PMID 9808187.
Vanhaesebroeck B, Higashi K, Raven C, et al. (1999). "Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.". EMBO J. 18 (5): 1292–302. doi:10.1093/emboj/18.5.1292. PMID 10064595.
Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.". Blood 97 (2): 352–8. PMID 11154208.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
Deregibus MC, Cantaluppi V, Doublier S, et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.". J. Biol. Chem. 277 (28): 25195–202. doi:10.1074/jbc.M200921200. PMID 11994280.
Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.". J. Immunol. 169 (1): 254–60. PMID 12077252.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
François F, Klotman ME (2003). "Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.". J. Virol. 77 (4): 2539–49. PMID 12551992.
Sadhu C, Masinovsky B, Dick K, et al. (2003). "Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement.". J. Immunol. 170 (5): 2647–54. PMID 12594293.