PIAS4

From Wikipedia, the free encyclopedia

Protein inhibitor of activated STAT, 4

Identifiers

PIAS4; FLJ12419; MGC35296; PIASY; Piasg; ZMIZ6

External IDs

OMIM: 605989 MGI: 2136940 HomoloGene: 41071

Gene ontology
Molecular Function:	• DNA binding • transcription corepressor activity • protein binding • zinc ion binding • SUMO ligase activity • metal ion binding
Cellular Component:	• nucleus • nuclear matrix
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • ubiquitin cycle • multicellular organismal development • negative regulation of transcription • protein sumoylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015897 (mRNA)
NP_056981 (protein)

NM_021501 (mRNA)
NP_067476 (protein)

Location

Chr 19: 3.96 - 3.99 Mb

Chr 10: 80.56 - 80.57 Mb

Pubmed search

[1]

[2]

Protein inhibitor of activated STAT, 4, also known as PIAS4, is a human gene.^[1]

[edit] References

^ Entrez Gene: PIAS4 Protein inhibitor of activated STAT, 4.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Liu B, Liao J, Rao X, et al. (1998). "Inhibition of Stat1-mediated gene activation by PIAS1.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10626–31. PMID 9724754.
Liu B, Gross M, ten Hoeve J, Shuai K (2001). "A transcriptional corepressor of Stat1 with an essential LXXLL signature motif.". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3203–7. doi:10.1073/pnas.051489598. PMID 11248056.
Nelson V, Davis GE, Maxwell SA (2001). "A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis.". Apoptosis 6 (3): 221–34. PMID 11388671.
Gross M, Liu B, Tan J, et al. (2001). "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.". Oncogene 20 (29): 3880–7. doi:10.1038/sj.onc.1204489. PMID 11439351.
Sachdev S, Bruhn L, Sieber H, et al. (2001). "PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.". Genes Dev. 15 (23): 3088–103. PMID 11731474.
Ohmine K, Ota J, Ueda M, et al. (2002). "Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells.". Oncogene 20 (57): 8249–57. doi:10.1038/sj.onc.1205029. PMID 11781839.
Tan JA, Hall SH, Hamil KG, et al. (2002). "Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators.". J. Biol. Chem. 277 (19): 16993–7001. doi:10.1074/jbc.M109217200. PMID 11877418.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Subramanian L, Benson MD, Iñiguez-Lluhí JA (2003). "A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.". J. Biol. Chem. 278 (11): 9134–41. doi:10.1074/jbc.M210440200. PMID 12511558.
Dahle Ø, Andersen TØ, Nordgård O, et al. (2003). "Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner.". Eur. J. Biochem. 270 (6): 1338–48. PMID 12631292.
Yamamoto H, Ihara M, Matsuura Y, Kikuchi A (2003). "Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.". EMBO J. 22 (9): 2047–59. doi:10.1093/emboj/cdg204. PMID 12727872.
Lee PS, Chang C, Liu D, Derynck R (2003). "Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling.". J. Biol. Chem. 278 (30): 27853–63. doi:10.1074/jbc.M301755200. PMID 12740389.
Chun TH, Itoh H, Subramanian L, et al. (2003). "Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy.". Circ. Res. 92 (11): 1201–8. doi:10.1161/01.RES.0000076893.70898.36. PMID 12750312.
Imoto S, Sugiyama K, Muromoto R, et al. (2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3.". J. Biol. Chem. 278 (36): 34253–8. doi:10.1074/jbc.M304961200. PMID 12815042.
Galleguillos D, Vecchiola A, Fuentealba JA, et al. (2004). "PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1.". J. Biol. Chem. 279 (3): 2005–11. doi:10.1074/jbc.M308113200. PMID 14559918.
Gross M, Yang R, Top I, et al. (2004). "PIASy-mediated repression of the androgen receptor is independent of sumoylation.". Oncogene 23 (17): 3059–66. doi:10.1038/sj.onc.1207443. PMID 14981544.
Zoumpoulidou G, Jones MC, Fernandez de Mattos S, et al. (2005). "Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y).". Mol. Endocrinol. 18 (8): 1988–99. doi:10.1210/me.2003-0467. PMID 15155784.
Imoto S, Sugiyama K, Yamamoto T, Matsuda T (2004). "The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.". Biochem. Biophys. Res. Commun. 319 (1): 275–82. doi:10.1016/j.bbrc.2004.04.161. PMID 15158472.