Physiologically-based pharmacokinetic modelling

From Wikipedia, the free encyclopedia

Physiologically-based pharmacokinetic modeling (PBPK) is a mathematical modelling technique for prediction of the absorption, distribution, metabolization and excretion (ADME) of a compound in humans and other species used in pharmaceutical research. PBPK modeling is also used in human risk assessment from industrial and environmental chemical exposure.

[edit] Bibliography

• Reddy, M. et al. (2005) Physiologically Based Pharmacokinetic Modeling : Science and Applications

[edit] Forums

• pbpk.org

[edit] Software

• acslXtreme software for PBPK modeling
• Simcyp Simulator Simcyp - Population-based pharmacokinetic modelling and simulation
• PK-Sim - Physiologically based pharmacokinetic modelling and simulation
• Quantum - Pharmacokinetic modelling