Talk:Phosphoinositide 3-kinase

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Would it not be simpler to use the abbreviation PI3K? It is now used in most publications, it is unambigous and easier to type.

[edit] Clean-up

This article is growing from a little stub into a fully grown piece, but needs a little bit of formatting and tidying up to help it along.....so I added in the clean-up tag Ciar 06:17, 11 December 2006 (UTC)

[edit] Wikipedia Cell Signaling Project

Should this article be incorporated into the wikipedia cell signaling project? (http://en.wikipedia.org/wiki/Wikipedia:WikiProject_Cell_Signaling) The involvement of PI3K seems to be important in signalling PKB activation, and probably a whole lot of other proteins. --Sinkingpie 00:07, 23 January 2007 (UTC)

It is as important as Rho GTPases or MAP Kinases in global cell signalling, so I would say yes Mammal4 09:00, 23 January 2007 (UTC)

PI3K signalling appears to be incorporated very heavily into a lot of cell biology.

It has been shown to be activated on response to T cell antigen, Cytokines, Growth Factors, Heterotrimeric and small G proteins, Tyrosine Kinases and probably many more.

And the products, PIP, PIP2 and PIP3 have been shown to affect:

DNA synthesis, Cell survival, Membrane ruffling, Oxidative burst, chemotaxis, cytoskeletal rearrangements, oocyte maturation, receptor internalisation, glucose transport, vesicle trafficking. --JamMan 14:51, 8 May 2007 (UTC)

[edit] Phosphatidylinositol 3-kinase or Phosphoinositide 3-kinase

Which is correct, I'd go for the former as that's its substrate but no one's picked up on this yet so...--JamMan 14:52, 8 May 2007 (UTC)

Phosphoinositide 3-kinase is correct as PI3Ks can phophorylate PtdIns(4,5)P2 in addition to phosphatidylinositol itself. Phosphoinositide is used as a generic term to refer to all the different phosphorylated variants. —Preceding unsigned comment added by Klausokken (talk • contribs) 09:28, 23 January 2008 (UTC)

==Figure is mislabelled, structure is of PI3k gamma not alpha

my bad. thanks for catching it. Roadnottaken 04:54, 14 July 2007 (UTC)