Phosphoribosyl-ATP diphosphatase

From Wikipedia, the free encyclopedia

In enzymology, a phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) is an enzyme that catalyzes the chemical reaction

1-(5-phosphoribosyl)-ATP + H₂O 1-(5-phosphoribosyl)-AMP + diphosphate

Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H₂O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase. This enzyme participates in histidine metabolism. It employs one cofactor, H+.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1Y6X, 1YVW, 1YXB, and 2A7W.

[edit] References

• IUBMB entry for 3.6.1.31
• BRENDA references for 3.6.1.31 (Recommended.)
• PubMed references for 3.6.1.31
• PubMed Central references for 3.6.1.31
• Google Scholar references for 3.6.1.31
• Smith DWE and Ames BN (1965). "Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis". J. Biol. Chem. 240: 3056–3063. 

[edit] External links

The CAS registry number for this enzyme class is 69553-55-5.

• IUBMB entry for 3.6.1.31

• KEGG entry for 3.6.1.31

• BRENDA entry for 3.6.1.31

• NiceZyme view of 3.6.1.31

• EC2PDB: PDB structures for 3.6.1.31

• PRIAM entry for 3.6.1.31

• PUMA2 entry for 3.6.1.31

• IntEnz: Integrated Enzyme entry for 3.6.1.31

• MetaCyc entry for 3.6.1.31

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004636: phosphoribosyl-ATP diphosphatase

• AMIGO entry for GO code 0004636: phosphoribosyl-ATP diphosphatase