Phosphoribokinase

From Wikipedia, the free encyclopedia

In enzymology, a phosphoribokinase (EC 2.7.1.18) is an enzyme that catalyzes the chemical reaction

ATP + D-ribose 5-phosphate ADP + D-ribose 1,5-bisphosphate

Thus, the two substrates of this enzyme are ATP and D-ribose 5-phosphate, whereas its two products are ADP and D-ribose 1,5-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-ribose-5-phosphate 1-phosphotransferase. This enzyme is also called phosphoribokinase (phosphorylating).

[edit] References

• IUBMB entry for 2.7.1.18
• BRENDA references for 2.7.1.18 (Recommended.)
• PubMed references for 2.7.1.18
• PubMed Central references for 2.7.1.18
• Google Scholar references for 2.7.1.18
• Krebs EG (1966). "Phosphorylase b kinase from rabbit muscle". Methods Enzymol. 8: 543–546. 
• Scarano E (1953). "Quoted by H.M. Kalckar The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides". Biochim. Biophys. Acta 12: 250–264. doi:10.1016/0006-3002(53)90144-9. 

[edit] External links

The CAS registry number for this enzyme class is 9030-59-5.

• IUBMB entry for 2.7.1.18

• KEGG entry for 2.7.1.18

• BRENDA entry for 2.7.1.18

• NiceZyme view of 2.7.1.18

• EC2PDB: PDB structures for 2.7.1.18

• PRIAM entry for 2.7.1.18

• PUMA2 entry for 2.7.1.18

• IntEnz: Integrated Enzyme entry for 2.7.1.18

• MetaCyc entry for 2.7.1.18

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050195: phosphoribokinase

• AMIGO entry for GO code 0050195: phosphoribokinase