Phosphopentomutase

From Wikipedia, the free encyclopedia

In enzymology, a phosphopentomutase (EC 5.4.2.7) is an enzyme that catalyzes the chemical reaction

alpha-D-ribose 1-phosphate $\rightleftharpoons$ D-ribose 5-phosphate

Hence, this enzyme has one substrate, alpha-D-ribose 1-phosphate, and one product, D-ribose 5-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-ribose 1,5-phosphomutase. Other names in common use include phosphodeoxyribomutase, deoxyribose phosphomutase, deoxyribomutase, phosphoribomutase, alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate, phosphotransferase, and D-ribose 1,5-phosphomutase. This enzyme participates in pentose phosphate pathway and purine metabolism. It has 3 cofactors: D-ribose 1,5-bisphosphate, alpha-D-Glucose 1,6-bisphosphate, and 2-Deoxy-D-ribose 1,5-bisphosphate.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I09.

[edit] References

IUBMB entry for 5.4.2.7
BRENDA references for 5.4.2.7 (Recommended.)
PubMed references for 5.4.2.7
PubMed Central references for 5.4.2.7
Google Scholar references for 5.4.2.7
Hammer-Jespersen K, Munch-Petersen A (1970). "Phosphodeoxyribomutase from Escherichia coli. Purification and some properties". Eur. J. Biochem. 17: 397–407. PMID 4992818.
Kammen HO, Koo R (1969). "Phosphopentomutases. I. Identification of two activities in rabbit tissues". J. Biol. Chem. 244: 4888–93. PMID 5824563.
Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p. 407-477.