Phospholipid-hydroperoxide glutathione peroxidase
From Wikipedia, the free encyclopedia
In enzymology, a phospholipid-hydroperoxide glutathione peroxidase (EC 1.11.1.12) is an enzyme that catalyzes the chemical reaction
- 2 glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + 2 H2O
Thus, the two substrates of this enzyme are glutathione and lipid hydroperoxide, whereas its 3 products are glutathione disulfide, lipid, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is glutathione:lipid-hydroperoxide oxidoreductase. Other names in common use include peroxidation-inhibiting protein, PHGPX, peroxidation-inhibiting protein: peroxidase, glutathione, (phospholipid hydroperoxide-reducing), phospholipid hydroperoxide glutathione peroxidase, and hydroperoxide glutathione peroxidase. This enzyme participates in glutathione metabolism.
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[edit] Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2GS3 and 2OBI.
[edit] References
- IUBMB entry for 1.11.1.12
- BRENDA references for 1.11.1.12 (Recommended.)
- PubMed references for 1.11.1.12
- PubMed Central references for 1.11.1.12
- Google Scholar references for 1.11.1.12
- Ursini F, Maiorino M, Gregolin C (1985). "The selenoenzyme phospholipid hydroperoxide glutathione peroxidase". Biochim. Biophys. Acta. 839: 62–70. PMID 3978121.
[edit] External links
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- The CAS registry number for this enzyme class is 97089-70-8.
[edit] Gene Ontology (GO) codes
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