Phosphogluconate dehydratase
From Wikipedia, the free encyclopedia
In enzymology, a phosphogluconate dehydratase (EC 4.2.1.12) is an enzyme that catalyzes the chemical reaction
- 6-phospho-D-gluconate
2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
Hence, this enzyme has one substrate, 6-phospho-D-gluconate, and two products, 2-dehydro-3-deoxy-6-phospho-D-gluconate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-D-gluconate hydro-lyase. This enzyme participates in pentose phosphate pathway.
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[edit] Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.
[edit] References
- IUBMB entry for 4.2.1.12
- BRENDA references for 4.2.1.12 (Recommended.)
- PubMed references for 4.2.1.12
- PubMed Central references for 4.2.1.12
- Google Scholar references for 4.2.1.12
- MELOCHE HP, WOOD WA (1964). "THE MECHANISM OF 6-PHOSPHOGLUCONIC DEHYDRASE". J. Biol. Chem. 239: 3505–10. PMID 14245409.
[edit] External links
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- The CAS registry number for this enzyme class is 9024-33-3.
[edit] Gene Ontology (GO) codes
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