Phosphatidylinositol deacylase

From Wikipedia, the free encyclopedia

In enzymology, a phosphatidylinositol deacylase (EC 3.1.1.52) is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-D-myo-inositol + H₂O 1-acylglycerophosphoinositol + a carboxylate

Thus, the two substrates of this enzyme are 1-phosphatidyl-D-myo-inositol and H₂O, whereas its two products are 1-acylglycerophosphoinositol and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-phosphatidyl-D-myo-inositol 2-acylhydrolase. Other names in common use include phosphatidylinositol phospholipase A2, and phospholipase A2.

[edit] References

• IUBMB entry for 3.1.1.52
• BRENDA references for 3.1.1.52 (Recommended.)
• PubMed references for 3.1.1.52
• PubMed Central references for 3.1.1.52
• Google Scholar references for 3.1.1.52
• Gray NC, Strickland KP (1982). "The purification and characterization of a phospholipase A2 activity from the 106,000 X g pellet (microsomal fraction) of bovine brain acting on phosphatidylinositol". Can. J. Biochem. 60: 108–17. PMID 7083039. 
• Gray NC, Strickland KP (1982). "On the specificity of a phospholipase A2 purified from the 106,000 X g pellet of bovine brain". Lipids. 17: 91–6. doi:10.1007/BF02535181. PMID 7087686. 

[edit] External links

The CAS registry number for this enzyme class is 81604-94-6.

• IUBMB entry for 3.1.1.52

• KEGG entry for 3.1.1.52

• BRENDA entry for 3.1.1.52

• NiceZyme view of 3.1.1.52

• EC2PDB: PDB structures for 3.1.1.52

• PRIAM entry for 3.1.1.52

• PUMA2 entry for 3.1.1.52

• IntEnz: Integrated Enzyme entry for 3.1.1.52

• MetaCyc entry for 3.1.1.52

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050185: phosphatidylinositol deacylase

• AMIGO entry for GO code 0050185: phosphatidylinositol deacylase