Phosphatidylinositol-3,4-bisphosphate 4-phosphatase

From Wikipedia, the free encyclopedia

In enzymology, a phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H₂O 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate

Thus, the two substrates of this enzyme are 1-phosphatidyl-myo-inositol 3,4-bisphosphate and H₂O, whereas its two products are 1-phosphatidyl-1D-myo-inositol 3-phosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase. Other names in common use include inositol-3,4-bisphosphate 4-phosphatase, D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase, phosphoinositide 4-phosphatase, inositol polyphosphate 4-phosphatase, D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase, and inositol polyphosphate 4-phosphatase type II. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

[edit] References

• IUBMB entry for 3.1.3.66
• BRENDA references for 3.1.3.66 (Recommended.)
• PubMed references for 3.1.3.66
• PubMed Central references for 3.1.3.66
• Google Scholar references for 3.1.3.66
• Howell S, Barnaby RJ, Rowe T, Ragan CI, Gee NS (1989). "Evidence for at least four different inositol bisphosphatases in bovine brain". Eur. J. Biochem. 183: 169–72. doi:10.1111/j.1432-1033.1989.tb14909.x. PMID 2546770. 
• Norris FA, Auethavekiat V, Majerus PW (1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". J. Biol. Chem. 270: 16128–33. doi:10.1074/jbc.270.27.16128. PMID 7608176. 
• Norris FA, Atkins RC, Majerus PW (1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". J. Biol. Chem. 272: 23859–64. doi:10.1074/jbc.272.38.23859. PMID 9295334. 

[edit] External links

The CAS registry number for this enzyme class is 122653-78-5.

• IUBMB entry for 3.1.3.66

• KEGG entry for 3.1.3.66

• BRENDA entry for 3.1.3.66

• NiceZyme view of 3.1.3.66

• EC2PDB: PDB structures for 3.1.3.66

• PRIAM entry for 3.1.3.66

• PUMA2 entry for 3.1.3.66

• IntEnz: Integrated Enzyme entry for 3.1.3.66

• MetaCyc entry for 3.1.3.66

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016316: phosphatidylinositol-3,4-bisphosphate 4-phosphatase

• AMIGO entry for GO code 0016316: phosphatidylinositol-3,4-bisphosphate 4-phosphatase