Phosphatidylcholine-sterol O-acyltransferase

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In enzymology, a phosphatidylcholine---sterol O-acyltransferase (EC 2.3.1.43) is an enzyme that catalyzes the chemical reaction

phosphatidylcholine + a sterol $\rightleftharpoons$ 1-acylglycerophosphocholine + a sterol ester

Thus, the two substrates of this enzyme are phosphatidylcholine and sterol, whereas its two products are 1-acylglycerophosphocholine and sterol ester.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is phosphatidylcholine:sterol O-acyltransferase. Other names in common use include lecithin---cholesterol acyltransferase, phospholipid---cholesterol acyltransferase, LCAT (lecithin-cholesterol acyltransferase), lecithin:cholesterol acyltransferase, and lysolecithin acyltransferase. This enzyme participates in glycerophospholipid metabolism.

[edit] References

IUBMB entry for 2.3.1.43
BRENDA references for 2.3.1.43 (Recommended.)
PubMed references for 2.3.1.43
PubMed Central references for 2.3.1.43
Google Scholar references for 2.3.1.43
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Buckley JT, Halasa LN, MacIntyre S (1982). "Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase". J. Biol. Chem. 257: 3320–5. PMID 7061477.
Glomset JA (1968). "The plasma lecithins:cholesterol acyltransferase reaction". J. Lipid. Res. 9: 155–67. PMID 4868699.
Vahouny GV, Treadwell CR (1968). "Enzymatic synthesis and hydrolysis of cholesterol esters". Methods. Biochem. Anal. 16: 219–72. doi:10.1002/9780470110348.ch4. PMID 4877146.