Phosphatidylcholine-retinol O-acyltransferase

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In enzymology, a phosphatidylcholine---retinol O-acyltransferase (EC 2.3.1.135) is an enzyme that catalyzes the chemical reaction

phosphatidylcholine + retinol---[cellular-retinol-binding-protein] $\rightleftharpoons$ 2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein]

Thus, the two substrates of this enzyme are phosphatidylcholine and [[retinol---[cellular-retinol-binding-protein]]], whereas its two products are 2-acylglycerophosphocholine and [[retinyl-ester---[cellular-retinol-binding-protein]]].

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase. Other names in common use include lecithin---retinol acyltransferase, phosphatidylcholine:retinol-(cellular-retinol-binding-protein), and O-acyltransferase.

[edit] References

IUBMB entry for 2.3.1.135
BRENDA references for 2.3.1.135 (Recommended.)
PubMed references for 2.3.1.135
PubMed Central references for 2.3.1.135
Google Scholar references for 2.3.1.135
MacDonald PN, Ong DE (1988). "Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine". J. Biol. Chem. 263: 12478–82. PMID 3410848.
Saari JC, Bredberg DL (1989). "Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes". J. Biol. Chem. 264: 8636–40. PMID 2722792.